Monthly Archives: enero 2014

La Fundación Lilly, en desarrollo de sus objetivos estatutarios y dentro del programa de Apoyo a la Investigación, convoca los Premios Fundación Lilly de Investigación Biomédica Preclínica y Clínica 2014, para investigadores que hayan contribuido de forma significativa al desarrollo de la Biomedicina y las Ciencias de la Salud en España, y mantengan una actividad […]

J Clin Invest. 2014 Apr 1;124(4):1-13. doi: 10.1172/JCI72323. Epub 2014 Mar 18. Together, these results underscore the involvement of bone, among other tissues, in the disruption of whole-body glucose homeostasis resulting from a HFD and the involvement of insulin and osteocalcin cross-talk in glucose intolerance. Furthermore, our data indicate that insulin resistance develops in bone […]

The trabecular bone score (TBS) is a gray‐level textural metric that can be extracted from the two‐dimensional lumbar spine dual‐energy X‐ray absorptiometry (DXA) image. TBS is related to bone microarchitecture and provides skeletal information that is not captured from the standard bone mineral density (BMD) measurement. Based on these data, lumbar spine TBS holds promise […]

In conclusion, despite the huge impact of osteoporosis worldwide, our knowledge of bone genetics and biology remains remarkably incomplete. Our findings and models provide compelling genetic evidence of a novel molecular network regulating adult skeletal homeostasis in vivo, which may help identify new specific therapeutic targets against involution- al, inflammatory, or cancer‐induced bone wasting. Autor: […]