Monthly Archives: abril 2017

MicroRNAs are small, noncoding single-stranded RNAs that have emerged as important posttranscriptional regulators of gene expression, with an essential role in vertebrate development and different biological processes. This review highlights the recent advances in the function of miRNAs and their roles in bone remodeling and bone diseases. MicroRNAs (miRNAs) are a class of small (∼22 […]

Abdominal CT images obtained for other reasons can identify patients with osteoporosis BMD without additional radiation exposure or cost. Uncalibrated values at L1 can detect more osteoporosis patients with spinal compression fractures than DXA in oncologic patients. Osteoporos Int. 2017 Mar;28(3):983-990. doi: 10.1007/s00198-016-3804-3. Epub 2017 Jan 20. Más información Alacreu E, Moratal D, Arana E

OBJECTIVE: To determine the effects of a simple exercise program on the balance and strength of postmenopausal women with osteoporosis.CONCLUSION: The present study demonstrates that a physical exercise program based on balance and strength exercises, carried out with simple and readily available  equipment, is capable of significantly improving the strength and balance of women with […]

Denosumab, a monoclonal antibody to the receptor activator of nuclear factor-κB ligand (RANKL), might be a novel preventative therapy for BRCA1-mutation carriers at high risk of developing breast cancer. They tested the alternative but not mutually exclusive hypothesis that BRCA1 deficiency might cell-autonomously activate RANKL expression to generate cellular states with cancer stem cell (CSC)-like […]

Different model systems using osteoblastic cell lines have been developed to help understand the process of bone formation. Here, we report the establishment of two human osteoblastic cell lines obtained from primary cultures upon transduction of immortalizing genes. The resulting cell lines had no major J Bone Miner Metab. 2017 Mar;35(2):150-160. doi: 10.1007/s00774-016-0753-z. Epub 2016 […]

The aim of this study was to show the presence of phosphorus and calcium metabolism disorders and the presence of urine lithogenic factors in women with osteoporotic fracture without previous urinary lithiasis. A cross-sectional study including 55 women with osteoporotic fracture surgically treated in the Trauma Department. CONCLUSIONS: Women with osteoporotic fracture showed several lithogenic […]

Mesoporous bioactive glasses are recently gaining importance thanks to their bone regenerative properties.Moreover, the mesoporous nature of these materials makes them suitable for drug delivery applications, opening new lines in the field of bone therapies. Acta Biomater. 2017 Mar 1;50:114-126. Más información Polo L Gómez-Cerezo N, Aznar E, Vivancos JL, Sancenón F, Arcos D, Vallet-Regí […]

X-Linked hypophosphatemia (XLH) is the most common form of hereditary rickets caused by loss-of function mutations in the PHEX gene. XLH is characterized by hypophosphatemia secondary to renal phosphate wasting, inappropriately low concentrations of 1,25 dihydroxyvitamin D and high circulating levels of fibroblast growth factor 23 (FGF23).This review summarizes current knowledge on phosphorus metabolism in […]