27Abr 2017
MPubmed

Osteoid osteomas of the spine are benign bone tumors typically presenting with progressive pain without neurological deficit. This report presents a case of an osteoid osteoma in the lumbar spine associated with radicular pain.

Pain Pract. 2017 Mar 30. doi: 10.1111/papr.12577. Osteoid Osteoma: Benign Osteoblastic

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Nebreda CL, Vallejo R, Mayoral-Rojals V, Ojeda A

27Abr 2017
MPubmed

Long-term antiresorptives use has been linked to atypical subtrochanteric and diaphyseal femoral fractures (AFF), the pathogenesis of which is still unknown. In the present case report they present the results of analysis of bone chips from a 74-year old female patient that had been on alendronate, ibandronate and denosumab treatment, and who sustained an atypical femoral fracture, by histology, quantitative backscattered electron imaging, and Raman spectroscopic analysis.

Bone Rep. 2017 Mar 2;6:81-86. doi: 10.1016/j.bonr.2017.02.006. eCollection 2017

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Shabestari M, Eriksen EF, Paschalis EP, Roschger P, Gamsjaeger S, Klaushofer K, Berzlanovich A, Nogues X, Puig L, Diez-Perez A.

27Abr 2017
MPubmed

Uremic secondary hyperparathyroidism is a multifactorial and complex disease The alterations in the regulation of mineral metabolism, the development of bone disease and extraosseous calcifications are essential components of chronic kidney disease-mineral and bone disorder and have been associated with negative outcomes. An update of the leading therapeutic tolos available for the prevention and clinical management of secondary hyperparathyroidism, its diagnosis, and the main mechanisms and factors involved in the pathogenesis of the disease will be described in this review.

Rev Endocr Metab Disord. 2017 Mar;18(1):79-95. doi: 10.1007/s11154-017-9421-4

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Portillo MR, Rodríguez-Ortiz ME

27Abr 2017
MPubmed

Hip fractures (HF) are prevalent and involve high morbidity and mortality so improving their management is important. HF registries are a good way to improve knowledge about this condition and its quality of care, while at the same time reducing clinical variability, optimizing efficiency, improving outcomes, and reducing costs.

A literature search was conducted on several national hip fracture registries, and those that contain relevant information on the variables and their outcomes were selected.

The selected HF registries were compared using the parameters they measure as well as the outcomes in the different countries. The variables collected in the majority of the databases and those that give useful information are as follows: sociodemographic variables (age, sex, place of residence), clinical variables (function before and after HF, anesthesia risk as measured by the ASA score, type of fracture, type of surgery and anesthesia, and in-hospital and 1-month mortality), and healthcare variables (pre-operative and overall stay, presence of collaboration with orthogeriatrics or with any clinician in addition to the surgeon, secondary prevention of new fractures by assessing the fall risk, and need for osteoporosis treatment).

The recording of HF cases in different countries improves knowledge about handling this condition and its quality of care, while at the same time reducing clinical variability, optimizing efficiency, improving outcomes, and reducing costs. The debate on the variables that should be recorded is timely, such as organizing how to collect each measurement, and even trying to unify the national and international registries or using a current proposal such as the one from the Fragility Fracture Network.

Osteoporos Int. 2017 Apr;28(4):1157-1166. doi: 10.1007/s00198-016-3834-x

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Sáez-López P, Brañas F, Sánchez-Hernández N, Alonso-García N, González-Montalvo JI.

27Abr 2017
MPubmed

Biogenesis and function of microRNAs can be influenced by genetic variants in the pri-miRNA sequences leading to phenotypic variability. This study aims to identify single nucleotide polymorphisms (SNPs) affecting the expression levels of bone-related mature microRNAs and thus, triggering an osteoporotic phenotype.They measured BMD-associated microRNAs in trabecular bone from osteoporotic hip fractures comparing to non-osteoporotic bone by qPCR.

Sci Rep. 2017 Mar 31;7(1):516. doi: 10.1038/s41598-017-00641-7

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De-Ugarte L, Caro-Molina E, Rodríguez-Sanz M, García-Pérez MA, Olmos JM, Sosa-Henríquez M, Pérez-Cano R, Gómez-Alonso C, Del Rio L,Mateo-Agudo J, Blázquez-Cabrera JA, González-Macías J, Pino-Montes JD, Muñoz-Torres M, Diaz-Curiel M, Malouf J, Cano A, Pérez-Castrillon JL, Nogues X, Garcia-Giralt N, Diez-Perez A.

 

23Mar 2017
MPubmed

Few epidemiologic studies have explored risk factors for bone tumors in children, and the role of environmental factors needs to be analyzed. The objective of this study was to  ascertain the association between residential proximity to industrial plants and  urban areas and risk of bone tumors in children, taking into account industrial groups and toxic pollutants released. Findings support the need for more detailed exposure assessment of certain toxics released by these facilities.

Sci Total Environ. 2017 Feb 1;579:1333-1342. doi:10.1016/j.scitotenv.2016.11.131.

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García-Pérez J, Morales-Piga A, Gómez-Barroso D, Tamayo-Uria I, Pardo Romaguera E, López-Abente G, Ramis R.

23Mar 2017
MPubmed

The aim of this study was to examine whether alterations caused by diabetes in calcium homeostasis, expression of osteopontin and the microarchitecture of bone are corrected by exposure to vanadium. They conclude that treatment with 3 mg V per d of the glucose lowering agent bis(maltolato)oxovanadium(iv) causes a decrease in osteopontin mRNA, which could favour the normalization of changes in Ca homeostasis and bone microarchitecture, both at the cortical and trabecular levels, caused by diabetes.

Metallomics. 2017 Feb 14. doi: 10.1039/c6mt00272b

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Sanchez-Gonzalez C), Moreno L, Lopez-Chaves C, Nebot E, Pietschmann P, Rodriguez-Nogales A, Galvez J, Montes-Bayon M, Sanz-Medel A, Llopis J.

23Mar 2017
MPubmed

Oxidative stress has been related to this bone loss, making dietary compounds with antioxidant properties a promising weapon. Male Wistar rats were maintained on diets with fish oil as unique fat source, supplemented or not with coenzyme Q10 (CoQ10). BMD was evaluated in the femur. Serum osteocalcin, osteopontin, receptor activator of nuclear factor-κB ligand, ostroprotegerin, parathyroid hormone, urinary F₂-isoprostanes, and lymphocytes DNA strand breaks were also measured. Reduced oxidative stress associated to CoQ10 supplementation of this n-3 PUFA-rich diet might explain the  higher BMD found in aged rats in this group of animals.

Nutrients. 2017 Feb 22;9(2). pii: E176. doi: 10.3390/nu9020176.

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Varela-López A, Ochoa JJ, Llamas-Elvira JM, López-Frías M, Planells E, Ramirez-Tortosa M, Ramirez-Tortosa CL, Giampieri F, Battino M, Quiles JL.

23Mar 2017
MPubmed

Bone defects may impede normal biomechanics and the structural stability of bone as an organ. In many cases, the correction of bone defects requires extensive surgical intervention involving the use of bone-grafting techniques and other procedures in which healing is slow, there is a high risk of infection and considerable pain is provoked – with no guarantee of complete correction of the defect. Therefore, the search for surgical alternatives continues to present a major challenge in orthopaedic traumatology.

World J Orthop. 2017 Feb 18;8(2):87-98. doi: 10.5312/wjo.v8.i2.87. eCollection 2017.

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Guerado E, Caso E