20Ene 2017
MPubmed

Pediatr Infect Dis J. 2016 Dec 21.

This study determines the prevalence and risk factors associated with low bone mineral density (BMD) in vertically HIV-infected patients; and to investigate whether low BMD is related to immune activation and senescence induced by HIV infection.

 

Autor: Jiménez B,Sainz T,Díaz L,Mellado MJ,Navarro ML,Rojo P,Glez-Tomé MI,Prieto L,Martínez J,de José MI,Ramos JT,Muñoz-Fdez MÁ;Madrid Cohort of HIV-Infected Children&Adolescents Integrated in the Pediatric Branch-Spanish Nat AIDS Research Network(CoRISpe)

20Ene 2017
MPubmed

Antimicrob Chemother. 2016 Dec 20. pii: dkw504. doi: 10.1093/jac/dkw504.

Switching from PIs to dolutegravir in virologically suppressed HIV-infected individuals has not been assessed.

The principal aim was to assess the evolution of bone mineral density (BMD) when switching from a ritonavir-boosted PI to dolutegravir in HIV-infected  patients with osteopenia or osteoporosis.

CONCLUSIONS: Dolutegravir + Kivexa(®) was safe and well-tolerated in virologically suppressed patients receiving a PI-based regimen. The lipid profile was better, albeit without significant changes in BMD, probably because of the short follow-up.

 

Autor: Negredo E, Estrada V, Domingo P, Gutiérrez MD, Mateo GM, Puig J, Bonjoch A, Ornelas A, Echeverría P, Estany C, Toro J, Clotet B

20Ene 2017
MPubmed

Rheumatol Int. 2016 Dec 16.

GENIRA [Gender in Rheumatoid Arthritis (RA)] is a comprehensive project aimed at  studying gender differences in RA patients and how these differences impact on these patient outcomes. Women with RA present significantly worse disability and QOL outcomes than men; these differences can be explained by female gender-associated comorbidities such as depression and osteoporosis rather than gender per se.

 Watch The Channel (2016) Full Movie Online Streaming Online and Download

Autor: Aurrecoechea E, Llorca Díaz J, Diez Lizuain ML, McGwin G Jr,Calvo-Alen J

20Ene 2017
MPubmed

Epigenetics. 2016 Dec 16:0.

Insufficient activity of the bone-forming osteoblasts leads to low bone mass and  predisposes to fragility fractures. The functional capacity of mesenchymal stem cells (hMSCs), the precursors of osteoblasts, may be compromised in elderly individuals, in relation with the epigenetic changes associated with aging.Results point to two areas of potential interest for discovering new therapeutic targets for low bone mass disorders and bone regeneration: the mechanisms stimulating MSCs proliferation after fracture and those impairing their terminal differentiation.

 

Autor: Del Real A, Pérez-Campo FM, Fernández AF, Sañudo C, Ibarbia CG,Pérez-Núñez MI, Criekinge WV, Braspenning M, Alonso MA, Fraga MF, Riancho JA

20Ene 2017
MPubmed

Horm Metab Res. 2016 Dec;48(12):828-833.

Although normocalcemic and asymptomatic hyperparathyroidism (HPT) are becoming more common, they remain only partially understood. Parathyroid hormone (PTH) polymorphisms have been associated with disease severity in classical HPT. The aim of the present study was to evaluate the clinical effect of PTH polymorphism  (rs6254) in normocalcemic and asymptomatic HPT. A prospective study of 61 consecutive patients with normocalcemic or asymptomatic HPT was carried out.

 

Autor: Díaz-Soto G, Romero E, Pérez-Castrillón JL, Jauregui OI, de Luis Román D

20Ene 2017
MPubmed

Endocrinol Nutr. 2016 Dec;63(10):551-559.

High weight is a protective factor against osteoporosis and risk of fracture. In obesity, however, where overweight is associated to excess fat, this relationship does not appear to be so clear, excess weight has sometimes been associated to decreased bone mass.

 

Autor: López-Gómez JJ, Pérez Castrillón JL, de Luis Román DA

20Ene 2017
MPubmed

Histol Histopathol. 2016 Dec 16:11858.

Bone is one of the most adaptable tissues in the body as it is continuously subjected to load bearing. Mechanical stimulation is necessary for the development of the skeleton.In this review, we discuss the complexity and well-orchestrated events that occur in bone mechanotransduction, focusing on osteocyte viability as an important biological response in this respect.

 

Autor: Maycas M, Esbrit P, Gortázar AR

20Ene 2017
MPubmed

Med Clin (Barc). 2016 Dec 16;147(12):547-553

Fibrous dysplasia is a skeletal disorder that is associated with a wide spectrum of clinical manifestations. Although the treatment of choice is based on bisphosphonates, the therapeutic efficacy of these agents in the control of disease activity remains uncertain. This article reviews the current data available on the treatment of this disease as well as the preliminary data on new therapeutic approaches.

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Autor: Florez H, Peris P, Guañabens N