27Abr 2017

Denosumab, a monoclonal antibody to the receptor activator of nuclear factor-κB ligand (RANKL), might be a novel preventative therapy for BRCA1-mutation carriers at high risk of developing breast cancer. They tested the alternative but not mutually exclusive hypothesis that BRCA1 deficiency might cell-autonomously activate RANKL expression to generate cellular states with cancer stem cell (CSC)-like properties. Using isogenic pairs of normal-like human breast epithelial cells in  which the inactivation of a single BRCA1 allele results in genomic instability,we assessed the impact of BRCA1 haploinsufficiency on the expression status of RANK and RANKL.

Oncotarget. 2017 Mar 25. doi: 10.18632/oncotarget.16558.

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Cuyàs E, Corominas-Faja B, Muñoz-San Martín M, Martin-Castillo B, Lupu R, Brunet J, Bosch-Barrera J, Menendez JA.

27Abr 2017
MPubmed

Different model systems using osteoblastic cell lines have been developed to help understand the process of bone formation. Here, we report the establishment of two human osteoblastic cell lines obtained from primary cultures upon transduction of immortalizing genes. The resulting cell lines had no major

J Bone Miner Metab. 2017 Mar;35(2):150-160. doi: 10.1007/s00774-016-0753-z. Epub 2016 Apr 2.

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Pérez-Campo FM, May T, Zauers J, Sañudo C, Delgado-Calle J, Arozamena J, Berciano MT, Lafarga M, Riancho JA.

27Abr 2017
MPubmed

The aim of this study was to show the presence of phosphorus and calcium metabolism disorders and the presence of urine lithogenic factors in women with osteoporotic fracture without previous urinary lithiasis. A cross-sectional study including 55 women with osteoporotic fracture surgically treated in the Trauma Department. CONCLUSIONS: Women with osteoporotic fracture showed several lithogenic factors in the urine studies, mainly fasting hypercalciuria.

Minerva Endocrinol. 2017 Mar;42(1):41-45. doi: 10.23736/S0391-1977.16.02300-2.

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Ochoa-Hortal Rull MA, Cano-García MC, Arrabal-Martín M, Arrabal-Polo MA

27Abr 2017
MPubmed

Mesoporous bioactive glasses are recently gaining importance thanks to their bone regenerative properties.Moreover, the mesoporous nature of these materials makes them suitable for drug delivery applications, opening new lines in the field of bone therapies.

Acta Biomater. 2017 Mar 1;50:114-126.

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Polo L Gómez-Cerezo N, Aznar E, Vivancos JL, Sancenón F, Arcos D, Vallet-Regí M, Martínez-Máñez R.

27Abr 2017
MPubmed

X-Linked hypophosphatemia (XLH) is the most common form of hereditary rickets caused by loss-of function mutations in the PHEX gene. XLH is characterized by hypophosphatemia secondary to renal phosphate wasting, inappropriately low concentrations of 1,25 dihydroxyvitamin D and high circulating levels of fibroblast growth factor 23 (FGF23).This review summarizes current knowledge on phosphorus metabolism in XLH.

Rev Endocr Metab Disord. 2017 Mar;18(1):107-115.

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Fuente R, Gil-Peña H, Claramunt-Taberner D, Hernández O,Fernández-Iglesias A, Alonso-Durán L, Rodríguez-Rubio E, Santos F.

27Abr 2017
MPubmed

Bone morphogenetic protein-2 (BMP-2) is widely used in orthopedic surgery and bone tissue engineering because of its strong osteogenic activity. However, BMP-2 treatments have several drawbacks and many groups are actively exploring alternatives. The results showed that IGF-1 greatly enhanced the BMP-induced osteogenic differentiation of these cells in general and that the ALP activity in the cultures was higher when the combination was made with BMP-6 than with BMP-2

J Biomed Mater Res A. 2017 Mar 3

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Rico-Llanos GA, Becerra J, Visser R.

27Abr 2017

Gaucher disease (GD), one of the commonest lysosomal disorders (a global population incidence of 1:50,000), is characterized by beta-glucocerebrosidase deficiency. Some studies have demonstrated bone infiltration in up to 80% of patients, even if asymptomatic. Bone disorder remains the main cause of morbidity in these patients, along with osteoporosis, avascular necrosis, and bone infarcts. Enzyme replacement therapy (ERT) has been  shown to improve these symptoms.

This cross-sectional study included patients with type 1 Gaucher disease (GD1) selected from the Catalan Study Group on GD.

J Bone Miner Res. 2017 Mar 6.

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Herrera S, Pérez-López J, Moltó-Abad M, Güerri-Fernández R,Cabezudo E, Novelli S, Esteve J, Hernández A, Roig I,Solanich X, Prieto-Alhambra D, Nogués X, Díez-Pérez A.

27Abr 2017
MPubmed

The aim was to evaluate periodontal alteration and biochemical markers associated with bone turnover in chronic oral with dicoumarins anticoagulant treatment patients.

Med Oral Patol Oral Cir Bucal. 2017 Mar 1;22(2):e258-e263.

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López-Lacomba D, Roa-López A, González-Jaranay M, Gómez-Moreno G, Moreu G.

27Abr 2017
MPubmed

Osteoid osteomas of the spine are benign bone tumors typically presenting with progressive pain without neurological deficit. This report presents a case of an osteoid osteoma in the lumbar spine associated with radicular pain.

Pain Pract. 2017 Mar 30. doi: 10.1111/papr.12577. Osteoid Osteoma: Benign Osteoblastic

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Nebreda CL, Vallejo R, Mayoral-Rojals V, Ojeda A

27Abr 2017
MPubmed

Long-term antiresorptives use has been linked to atypical subtrochanteric and diaphyseal femoral fractures (AFF), the pathogenesis of which is still unknown. In the present case report they present the results of analysis of bone chips from a 74-year old female patient that had been on alendronate, ibandronate and denosumab treatment, and who sustained an atypical femoral fracture, by histology, quantitative backscattered electron imaging, and Raman spectroscopic analysis.

Bone Rep. 2017 Mar 2;6:81-86. doi: 10.1016/j.bonr.2017.02.006. eCollection 2017

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Shabestari M, Eriksen EF, Paschalis EP, Roschger P, Gamsjaeger S, Klaushofer K, Berzlanovich A, Nogues X, Puig L, Diez-Perez A.