08Abr 2014

Pharmacological inhibition of LPA1 receptor in the K/BxN serum-transfer arthritis model led to reduction of severity of arthritis involving multiple mechanisms, increased apoptosis, reduced inflammatory mediators and proteins involved in bone remodelling, that show LPA1 as a very promising target in rheumatoid arthritis treatment.

Autor: Orosa B, García S, Martínez P, González A, Gómez-Reino JJ, Conde C.

08Abr 2014

Bone-tissue engineering is a therapeutic target in the field of dental implant and orthopedic surgery. It is therefore essential to find a microenvironment

that enhances the growth and differentiation of osteoblasts both from mesenchymal stem cells (MSCs) and those derived from dental pulp.

The aim of this review is to determine the relationship among the proteins fibronectin (FN), osteopontin (OPN), tenascin (TN), bone sialoprotein (BSP), and bone morphogenetic protein (BMP2) and their ability to coat different types of biomaterials and surfaces to enhance osteoblast differentiation. Pre-treatment of biomaterials with FN during the initial phase of osteogenic differentiation on all types of surfaces, including slotted titanium and polymers, provides an ideal microenvironment that enhances adhesion, morphology, and proliferation of pluripotent and multipotent cells. Likewise, in the second stage of differentiation, surface coating with BMP2 decreases the diameter and the pore size of the scaffold, causing better adhesion and reduced proliferation of BMP-MSCs.

Autor: Chatakun P, Núñez-Toldrà R, Díaz López EJ, Gil-Recio C, Martínez-Sarrà E,…

08Abr 2014

In patients with prostate carcinoma, estrogen levels influence bone resorption and bone formation whereas androgens may exert actions only in bone resorption.

These results suggest that estradiol is the main sex steroid that regulates bone metabolism in males with prostate carcinoma.

Autor: Varsavsky M, Reyes-García R, García-Martín A, Rozas-Moreno P, González-Ramírez R, Muñoz-Torres M.

08Abr 2014

Iron deficiency is related with higher bone resorption in young women. Consumption of a dairy product that supplies 5 μg/day of vitamin D3 reduces bone turnover and increases circulating 25OHD to nearly reach an optimal vitamin D status, defined as 25OHD over 75 nmol/L.

Autor: Toxqui L, Pérez-Granados AM, Blanco-Rojo R, Wright I, de la Piedra C, Vaquero MP.

08Abr 2014

PTH (1-84) is able to restore the adverse effects of orchidectomy on bone as measured by BMD, microstructural and biomechanical properties and bone remodeling markers.

The purpose of this study was to evaluate the effect of parathyroid hormone (PTH) (1-84) in a model of male osteoporosis induced by orchidectomy in rats.

Autor: Martín-Fernández M, Martínez E, Díaz-Curiel M, Guede D, Caeiro JR, De la Piedra C.

08Abr 2014

Bone mineral density was similar between HIV-infected patients aged 20-30 years than in age- and gender-matched controls. However, lower femoral T-scores and higher rate of osteopenia and osteoporosis were seen in HIV-infected men.

Therapy with protease inhibitors, nadir CD4 counts, and fat and lean mass were predictive factors of peak bone mass. Given that these patients will be living with HIV infection for many years, every effort should be made to modify risk factors.