08Abr 2014

HIV infection is associated with an almost 3-fold increase in fracture risk compared to that of uninfected age and gender-matched uninfected patients.

HIV patients are also at an almost 9-fold higher risk of hip fracture.

Autor: Prieto-Alhambra D, Güerri-Fernández R, De Vries F, Lalmohamed A, Bazelier M,…

08Abr 2014

This review describes the most recent data on the effects of glucocorticoids on the Wnt signaling pathway, especially on their antagonists, sclerostin and Dkk-1.

Bone formation is suppressed in glucocorticoid-induced osteoporosis. One of the mechanisms by which glucocorticoids depress bone formation is through their effects on the Wnt/β-catenin signaling pathway, a critical regulator of osteoblastogenesis.

Autor: Guañabens N, Gifre L, Peris P.

08Abr 2014

Long-term adherence (five years) to diets that feature normal levels of calcium, low protein and low salt may reduce numbers of stone recurrences,

decrease oxaluria and calcium oxalate relative supersaturation indexes in people with idiopathic hypercalciuria who experience recurrent kidney stones.

Adherence to a low salt, normal calcium level diet for some months can reduce calciuria and oxaluria. However, the other dietary interventions examined did not demonstrate evidence of significant beneficial effects.No studies were found investigating the effect of dietary recommendations on other clinical complications or asymptomatic idiopathic hypercalciuria.

Autor: Escribano J, Balaguer A, Roqué i Figuls M, Feliu A, Ferre N.

08Abr 2014

In our study, postmenopausal women who live in rural populations have more poverty, lower values of vitamin D, lower BMD in the lumbar spine and a higher prevalence of vertebral fractures and of osteoporosis.

The higher prevalence of obesity, arterial hypertension and diabetes mellitus observed in these women may be adjuvant factors, all fostered by their socioeconomic state of poverty.

Autor: Gómez-de-Tejada Romero MJ, Navarro Rodríguez MD, Saavedra Santana P, Quesada Gómez JM, …

08Abr 2014

A particular subset of postmenopausal patients with high remodeling and/or low subchondral bone density may benefit from the treatment with bone-acting agents hindering OA progression.

This OA population could be identified with the simultaneous use of subchondral bone dual-energy X-ray absorptiometry and scintigraphy.

Autor: Roman-Blas JA, Castañeda S, Largo R, Lems WF, Herrero-Beaumont G.

08Abr 2014

The magnitude of the problem of osteoporosis in psoriatic arthritis seems to be mild.

To assess the bone mineral density (BMD) and the frequency of osteoporosis and clinical fractures in a large group of Spanish patients with psoriatic arthritis (PsA).

Autor: Busquets N, Vaquero CG2, Moreno JR, Vilaseca DR, Narváez J, Carmona L4, Nolla JM.

08Abr 2014

A high prevalence of secondary causes of osteoporosis is observed in HIV-infected patients, and its type and cumulative number determine a lower BMD, after adjusting by age and body mass index.

Eighty-one percent of human immunodeficiency virus (HIV)-infected patients had one or more of seven evaluated causes of secondary osteoporosis, and this rate increases with age. The type and number of causes were associated with a lower bone mineral density (BMD), and with an increased rate of osteopenia/osteoporosis, regardless of age and body mass index.

Autor: Casado JL, Bañon S, Andrés R, Perez-Elías MJ, Moreno A, Moreno S.

08Abr 2014

The incidence of fractures after spinal cord injury is high, with severity and time since spinal cord injury being the main determinants for their development. Fractures were frequently associated with clinical complications.

However, the use of anti-osteoporotic treatment was uncommon.

Autor: Gifre L, Vidal J, Carrasco J, Portell E, Puig J, Monegal A, Guañabens N, Peris P.

08Abr 2014

The results show that patients from all provinces in Spain with severe osteoporosis receiving teriparatide and enrolled in an educational support program had high persistence and satisfaction with the program.

However, no control group was included in these analyses and it is possible that selection bias occurred. It is suggested that patient-based strategies similar to this could be beneficial for all long-term treatments.

Autor: Nogues X, Luz Rentero M, Rodríguez AL.

08Abr 2014

Multiple juxta-articular deposits of hydroxyapatite causing calcific periarthritis may be a useful sign of hypophosphatasia, especially when the calcific periarthritis is familial.

ypophosphatasia (HPP) is the inborn error of metabolism that features low serum alkaline phosphatase (ALP) activity caused by loss-of-function mutation(s) within the gene for the tissue nonspecific isoenzyme of ALP (TNSALP). In HPP, extracellular accumulation of inorganic pyrophosphate (PPi), a TNSALP substrate and inhibitor of mineralization, leads frequently to premature tooth loss and often to rickets or osteomalacia. In affected adults, the excess PPi sometimes also causes calcium pyrophosphate dihydrate (CPPD) deposition, PPi arthropathy, or pseudogout, or seemingly paradoxical deposition of hydroxyapatite crystals in ligaments or around joints when the condition is called calcific periarthritis (CP).

Autor: Guañabens N, Mumm S, Möller I, González-Roca E, Peris P, Demertzis JL, Whyte MP.