08Abr 2014

The results suggest that matrix Gla protein genetic variations could predict a higher risk of bone loss and progression of vascular calcification in men.

Two matrix Gla protein (MGP) polymorphisms were associated with progression of aortic calcification and femoral neck bone loss in men. All these findings were also functionally corroborated in two vascular and bone in vitro systems indicating that MGP genetic variations can be partly responsible of higher risk of bone loss and vascular calcification.

Autor: Tuñón-Le Poultel D, Cannata-Andía JB, Román-García P, Díaz-López JB,

08Abr 2014

Our results show: (i) retinoic acid affects proliferative and mineralogenic activities in two fish skeletal cell types and (ii) that during phenotype transitions, specific retinoic acid nuclear receptors and bone-related genes are differentially expressed in a cell type-dependent manner.

Autor: Fernández I, Tiago DM, Laizé V, Leonor Cancela M, Gisbert E.

08Abr 2014

In spite of the fact that this study does not have a large enough sample, our data suggest that HT used in the early years of menopause does not present a long-term protective effect on vertebral fracture after discontinuing treatment.

Autor: Castelo-Branco C, Davila J, Perelló MF, Peguero A, Ros C, Martínez-Serrano MJ, Balasch J.

08Abr 2014

We provide strong and significant evidence from both linkage and association analyses that the SOST gene may affect the strength of the femoral shaft.

Future investigations should study the relationship between bone mass formation and strength properties of the bones.

Autor: Athanasiadis G1, Malouf J, Hernandez-Sosa N, Martin-Fernandez L,…

08Abr 2014

Circulating sclerostin levels are significantly increased in patients with prostate cancer and particularly in those receiving androgen deprivation therapy.

The inverse relationship between serum sclerostin and testosterone in these patients suggests that androgens are key regulators of bone metabolism in this population.

Autor: García-Fontana B, Morales-Santana S, Varsavsky M, García-Martín A,…

08Abr 2014

Self-reported hip fracture is a common condition among community-living elderly population in Spain, and has a significant impact upon long-term all-cause mortality.

There is a paucity of data concerning the specific associations between hip fracture in the elderly and other age-related conditions, as well as its impact on long-term survival.

Autor: Fernández-Ruiz M, Guerra-Vales JM, Trincado R, Medrano MJ, Benito-León J, Bermejo-Pareja F.

08Abr 2014

Pharmacological inhibition of LPA1 receptor in the K/BxN serum-transfer arthritis model led to reduction of severity of arthritis involving multiple mechanisms, increased apoptosis, reduced inflammatory mediators and proteins involved in bone remodelling, that show LPA1 as a very promising target in rheumatoid arthritis treatment.

Autor: Orosa B, García S, Martínez P, González A, Gómez-Reino JJ, Conde C.

08Abr 2014

Bone-tissue engineering is a therapeutic target in the field of dental implant and orthopedic surgery. It is therefore essential to find a microenvironment

that enhances the growth and differentiation of osteoblasts both from mesenchymal stem cells (MSCs) and those derived from dental pulp.

The aim of this review is to determine the relationship among the proteins fibronectin (FN), osteopontin (OPN), tenascin (TN), bone sialoprotein (BSP), and bone morphogenetic protein (BMP2) and their ability to coat different types of biomaterials and surfaces to enhance osteoblast differentiation. Pre-treatment of biomaterials with FN during the initial phase of osteogenic differentiation on all types of surfaces, including slotted titanium and polymers, provides an ideal microenvironment that enhances adhesion, morphology, and proliferation of pluripotent and multipotent cells. Likewise, in the second stage of differentiation, surface coating with BMP2 decreases the diameter and the pore size of the scaffold, causing better adhesion and reduced proliferation of BMP-MSCs.

Autor: Chatakun P, Núñez-Toldrà R, Díaz López EJ, Gil-Recio C, Martínez-Sarrà E,…

08Abr 2014

In patients with prostate carcinoma, estrogen levels influence bone resorption and bone formation whereas androgens may exert actions only in bone resorption.

These results suggest that estradiol is the main sex steroid that regulates bone metabolism in males with prostate carcinoma.

Autor: Varsavsky M, Reyes-García R, García-Martín A, Rozas-Moreno P, González-Ramírez R, Muñoz-Torres M.