30Ene 2017
MPubmed

Fragility fractures of the hip have a major impact on the lives of patients and their families. This study highlights significant geographical variation in secondary fracture prevention with even the highest performing regions failing the majority of patients despite robust evidence supporting the benefits of diagnosis and treatment. CONCLUSIONS: Significant geographic differences exist in prescribing of anti-osteoporosis drugs after hip fracture despite adjustment for potential confounders. Further work examining differences in health care provision may inform strategies to improve secondary fracture prevention after hip fracture.Watch Full Movie Online Streaming Online and Download

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Shah A, Prieto-Alhambra D, Hawley S, Delmestri A, Lippett j,Cooper C, Judge A, Javaid MK; REFReSH study team.

20Ene 2017
MPubmed

J Am Soc Nephrol. 2016 Dec 7

Parathyroid hormone (PTH) is a primary calcium regulatory hormone. Elevated serum PTH concentrations in primary and secondary hyperparathyroidism have been associated with bone disease, hypertension, and in some studies, cardiovascular mortality. Genetic causes of variation in circulating PTH concentrations are incompletely understood. This study performed a genome-wide association study of serum PTH concentrations among 29,155 participants of European ancestry from 13 cohort  studies.

 

Autor: RobinsonCC,LutseyPL,KleberME,NielsonCM,MitchellBDBisJC,EnyKMPortasL,ErikssonJ,LorentznM,KollerDLMilaneschiY,TeumerA,PilzS,NethanderM,SelvinE,TanGW,WengLC,WongHS,LaiD,PeacockM,HannemannA,VölkerU,HomuthG,NaukM,MurgiaF,PatteeJW,OrwollE,ZmudaJM,RianchoJA

20Ene 2017
MPubmed

J Bone Miner Res. 2016 Dec 7. doi: 10.1002/jbmr.3051.Watch movie online The Transporter Refueled (2015)

The majority of osteoporosis medications are antiresorptive agents, which reduce the rate of bone remodeling. Within this group are the bisphosphonates, which inhibit protein prenylation in the mature osteoclast, reducing osteoclast capacity to resorb bone(1) and denosumab, a monoclonal antibody to rank ligand that inhibits osteoclast formation, function and survival. Although several new anabolic agents are in development(3-5) , teriparatide is currently the only  available anabolic therapy for osteoporosis in the United States, with the addition of only PTH(1-84) in the EU [referred to as PTH).

 

Autor: Cosman F, Nieves JW, Dempster D

20Ene 2017
MPubmed

Calcif Tissue Int. 2016 Dec 7Watch Full Movie Online Streaming Online and Download

The adipokine adiponectin affects multiple target tissues and plays important roles in glucose metabolism and whole-body energy homeostasis. Circulating adiponectin levels in obese people are lower than in non-obese, and increased serum adiponectin is associated with weight loss. Results of these studies are not entirely congruent, partly due to variation among experimental systems and partly due to the complex nature of adiponectin signaling, which involves a combination of multiple direct and indirect mechanisms.

 

Autor: Naot D, Musson DS, Cornish J

20Ene 2017
MPubmed

Curr Osteoporos Rep. 2016 Dec;14(6):320-326.

Diabetic patients have a higher fracture risk than expected by their bone mineral density (BMD). Poor bone quality is the most suitable and explainable cause for the elevated fracture risk in this population. Advanced glycation end products (AGEs), physically affect the properties of the bone material, one of a component of bone quality, through their accumulation in the bone collagen fibers.

 

Autor: Yamamoto M, Sugimoto T

20Ene 2017
MPubmed

Clin Orthop Surg. 2016 Dec;8(4):437-443.

Bisphosphonates are generally known to adversely affect fracture healing because they inhibit osteoclastic bone resorption. A total of 82 osteoporotic patients who underwent locking plate fixation of proximal humerus fractures were enrolled  retrospectively. This study shows that the early initiation of bisphosphonate treatment does not affect bone union or clinical outcomes in patients with an osteoporotic proximal humerus fracture treated by locking compression plate fixation.

 

Autor: Seo JB, Yoo JS, Ryu JW, Yu KW.

13Dic 2016
MPubmed

J Bone Joint Surg Am. 2016 Nov 16;98(22):1868-1878.

Osteoporosis drugs might affect fracture-healing. We therefore studied the effects of teriparatide in comparison with risedronate on recovery after pertrochanteric hip fractures. Teriparatide was associated with less pain and a shorter time to complete the TUG test between 6 and 26 weeks compared with risedronate. Other fracture-recovery outcomes were similar. The results should be interpreted with caution as these were secondary end points.

Autor: Aspenberg P, Malouf J, Tarantino U, García-Hernández P, Corradini C, Overgaard S, Stepan JJ, Borris , Lespessailles E,Frihagen F, Papavasiliou K, Petto H, Caeiro JR, Marin F
13Dic 2016
NEJM

New England Journal of Medicine, November 10, 2016 Vol. 375 No. 19, p 1817-1820.J.E.

The claim that large proportions of North American and other populations are deficient in vitamin D is based on misinterpretation and misapplication of the Institute of Medicine reference values for nutrients — misunderstandings that can adversely affect patient care.

Autor: Manson, P.M. Brannon, C.J. Rosen, and C.L. Taylor.
13Dic 2016
MPubmed

J Cell Physiol. 2016 Nov 18. doi: 10.1002/jcp.25693.
This article reviews the current body of knowledge on regulation of Hcy mediated oxidative stress and its role in bone remodeling, vascular blood flow and progression of bone disease. This article is protected by copyright. All rights reserved.

Autor: Behera J, Bala J, Nuru M, Tyagi SC, Tyagi N

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13Dic 2016
MPubmed

Osteoporos Int. 2016 Dec;27(12):3395-3407

Counseling for patients with primary hyperparathyroidism (PHPT) and mild hypercalcemia without indications for surgical intervention requires accurate estimates of the potential benefits of parathyroidectomy. Patients with mild PHPT without indications for surgery experience a limited number of adverse consequences during short-term follow-up limiting our ability to estimate the benefit of surgery during this timeframe. This information is helpful as these patients consider surgery versus active surveillance. Long-term data is warranted to determine who benefits in the long run from surgical intervention and the extent to which this benefit affects outcomes that matter to patients.

Autor: Singh Ospina N, Maraka S, Rodriguez-Gutierrez R, Espinosa de Ycaza AE, Jasim S, Gionfriddo M, Castaneda-Guarderas A, Brito JP, Al Nofal A, Erwin P, Wermers R, Montori V