04Dic 2013
Springer

Calcified Tissue International (2014) 94:4: 423-432

They conclude that Cnr2 deficiency affects expression of a large number of genes in different strains of mice, and that these differences are likely to be responsible in part for the differences in skeletal phenotype that they and others have observed in mice with defective cannabinoid receptor signalling in different genetic backgrounds.

Autor: Sophocleous A, Sims AH, Idris AI, Ralston SH
04Dic 2013
Springer

Osteoporos Int (2014) 25:1267–1274. DOI 10.1007/s00198-013-2586-0.

Conclusions This study supports other international studies by showing changes in the incidence of hip fractures after age population adjustment, which denotes a decrease in the younger age groups and among women and shows an increase in both groups over 85 years. The increase in the crude incidence rate of hip fracture in Spain reflects changes in population structure.

Autor: Azagra R, L-Expósito F, Martin-S JC, Aguyé A, Moreno N, Cooper C, D-Pérez A, Dennison EM
04Dic 2013
Springer

The results of this nested case–control study in the CPRD indicate no evidence for a higher risk of MI or cardiovascular death associated with the use of strontium ranelate

in women treated for osteoporosis compared with non-use of this agent in routine medical practice in the UK.

Autor: C. Cooper, K. M. Fox, J. S. Borer
04Dic 2013
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In conclusion, our data highlight the potential for novel drug targeting approaches in rare skeletal disorders ranging from severe skeletal fragility to sclerosing bone overgrowth through selective modulation of canonical WNT signaling.

These approaches should also be beneficial in the context of other medical conditions with much less severe phenotypes, such as postmenopausal osteoporosis, given the crucial role of this potent bone anabolic pathway for skeletal homeostasis

Autor: Ming‐Kang Chang, Ina Kramer, Hansjoerg Keller,…
04Nov 2013
Springer

Osteoporos Int (2014) 25:1225–1235

This is the first network meta-analysis to assess the comparative GI safety of bisphosphonates for primary osteoporosis. Our results identify zoledronic acid as having the highest probability of having the greatest number of GI adverse events and nausea. Discontinuation due to adverse events may be a more clinically relevant outcome, with the highest probability of greatest occurrence found with etidronate and zoledronic acid. These results question the assumption that annual zoledronic acid will translate into better adherence. Little difference was found between alendronate and risedronate for serious AE. More research into real-world implications of the comparative safety of bisphosphonates is needed.

Autor: M. Tadrous, L. Wong,M. M. Mamdani,D. N. Juurlink ,M. D. Krahn,L. E. Lévesque ,S. M. Cadarette
04Sep 2013
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J Bone Miner Res, (2014) 29; 787–795

The findings represent the first demonstration, using a direct in vivo measure of BMS, of compromised bone material properties in patients with T2D. Further, our results confirm previous studies demonstrating low bone turnover in patients with T2D and highlight the potential detrimental effects of prolonged hyperglycemia on bone quality. Thus, the skeleton needs to be recognized as another important target tissue subject to diabetic complications.

Autor: J N Farr,1 M T Drake,1 S Amin,2 L J Melton III,3 L K McCready,1 Sundeep Khosla1
04Ago 2013
Springer

In conclusion, baseline cardiovascular diseases are common in patients treated with strontium ranelate, with more than half of strontium ranelate users being current

users of antiplatelet drugs or having a history of cerebrovascular disease, peripheral vascular disease or myocardial infarction. Moreover, this observational study shows an increased confounder-adjusted mortality risk in patients treated with strontium ranelate compared with other osteoporosis drugs.

Autor: B. Abrahamsen, E. L. Grove, P. Vestergaard
04Jun 2013
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Froedtert Healthcare, Patient Care Services, Milwaukee, WI, USA, ryanpa@uwm.edu.

Ryan P, Schlidt A, Ryan C
Froedtert Healthcare, Patient Care Services, Milwaukee, WI, USA, ryanpa@uwm.edu.
Osteoporosis International : a Journal Established as Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA [2013]

Autor: Journal Established as Result of Cooperation Between…
04Feb 2013
american-journal-of-medicine-logo

Vertebral fractures detected “incidentally” by chest radiograph usually do not trigger osteoporosis treatment in older patients.

Background

Vertebral fractures detected “incidentally” by chest radiograph usually do not trigger osteoporosis treatment in older patients. In a 3-arm controlled trial we reported that both physician-directed and enhanced (physician plus patient activation) interventions increased treatment rates more than 10-fold (15%-20% absolute increases) compared with usual care; the cost-effectiveness of these interventions is unknown.

Sumit R. Majumdar, MD, MPHcorrespondencePress enter key for correspondence informationemailPress enter key to Email the author, Douglas A. Lier, MA, Finlay A. McAlister, MD, MSc, Brian H. Rowe, MD, MSc, Kerry Siminoski, MD, David A. Hanley, MD, Anthony S. Russell, MD, Jeffrey A. Johnson, PhD

04Oct 2012
Springer

In paired biopsies of osteoporotic women treated with either strontium ranelate or a placebo for 36 months, characteristics of bone apatite crystals were not influenced by the presence of strontium.

Summary

In paired biopsies of osteoporotic women treated with either strontium ranelate or a placebo for 36 months, characteristics of bone apatite crystals were not influenced by the presence of strontium. The mean rate of substitutions of calcium by strontium ions was 4.5 %.

Autor: A. Doublier, D. Farlay, X. Jaurand, R. Vera, G. Boivin