04Mar 2015

Calcif Tissue Int (2015) 96:500–509 DOI 10.1007/s00223-015-9980-x

They have demonstrated that lumbar spine texture analysis using TBS is a risk factor for osteoporotic fracture and also for risk of death. The predictive ability of TBS is independent of FRAX clinical risk factors and femoral neck BMD; finally we have derived an algorithm to adjust probability of fracture from clinical risk factors and BMD to account for TBS, an approach that will require validation in further independent cohorts.

Autor: McCloskey EV, Odén A, Harvey NC, Leslie WD, Hans D, Johansson H, Kanis JA.
04Feb 2015

Osteoporos Int. 2015 Feb;26(2):431-41. doi: 10.1007/s00198-014-2903-2. Epub 2014 Sep 30.

Early administration of BPs after surgery did not appear to delay fracture healing time either radiologically or clinically. Furthermore, according to the changes in BMD and bone turnover markers, the anti-resorptive efficacy of BPs given immediately after surgical repair should positively affect the rate of subsequent fractures.

Autor: Li YT, Cai HF, Zhang ZL.
04Feb 2015

Osteoporos Int. 2015 Feb;26(2):645-52. doi: 10.1007/s00198-014-2919-7.

Hip fracture is independently associated with increased risk of developing stroke. In addition, the risk of stroke following incidence of hip fracture is more prominent in younger patients, men, those with cardiovascular comor- bidities, and in patients using specific medication, such as diuretics and ABRs. Given the subsequent higher risk of stroke among patients with hip fracture, our study results indicate that physicians should be proactive to prevent strokes.

Autor: Tsai CH, Lin CL, Hsu HC, Chung WS
04Feb 2015

Osteoporos Int. 2015 Feb;26(2):449-58. doi: 10.1007/s00198-014-2813-3

The meta-analysis indicates that BMD is low in predialysis and dialysis patients with fractures. These findings, considered together with the recent prospective study in CKD, and post hoc analyses of the pivotal fracture trials suggests that BMD may be clinically useful in assessing fracture risk in CKD, different than what has been suggested in the KDIGO guidelines .

Autor: Bucur RC, Panjwani DD, Turner L, Rader T, West SL, Jamal SA.
04Ene 2015

Proc Natl Acad Sci U S A. 2015 Jan 20. pii: 201409857.

Thus, activation of osteocytic β-catenin signaling increases both osteoclasts and osteoblasts, leading to bone gain, and is sufficient to activate the Notch pathway. These findings demonstrate disparate outcomes of β-catenin activation in osteocytes versus osteoblasts and identify osteocytes as central target cells of the anabolic actions of canonical Wnt/β-catenin signaling in bone.

Autor: Tu X,Delgado-Calle J,Condon KW,Maycas M,Zhang H,Carlesso N,Taketo M,Burr DB,Plotkin LI,Bellido T.