04Feb 2015

Osteoporos Int. 2015 Feb;26(2):645-52. doi: 10.1007/s00198-014-2919-7.

Hip fracture is independently associated with increased risk of developing stroke. In addition, the risk of stroke following incidence of hip fracture is more prominent in younger patients, men, those with cardiovascular comor- bidities, and in patients using specific medication, such as diuretics and ABRs. Given the subsequent higher risk of stroke among patients with hip fracture, our study results indicate that physicians should be proactive to prevent strokes.

Autor: Tsai CH, Lin CL, Hsu HC, Chung WS
04Feb 2015

Osteoporos Int. 2015 Feb;26(2):449-58. doi: 10.1007/s00198-014-2813-3

The meta-analysis indicates that BMD is low in predialysis and dialysis patients with fractures. These findings, considered together with the recent prospective study in CKD, and post hoc analyses of the pivotal fracture trials suggests that BMD may be clinically useful in assessing fracture risk in CKD, different than what has been suggested in the KDIGO guidelines .

Autor: Bucur RC, Panjwani DD, Turner L, Rader T, West SL, Jamal SA.
04Ene 2015

Proc Natl Acad Sci U S A. 2015 Jan 20. pii: 201409857.

Thus, activation of osteocytic β-catenin signaling increases both osteoclasts and osteoblasts, leading to bone gain, and is sufficient to activate the Notch pathway. These findings demonstrate disparate outcomes of β-catenin activation in osteocytes versus osteoblasts and identify osteocytes as central target cells of the anabolic actions of canonical Wnt/β-catenin signaling in bone.

Autor: Tu X,Delgado-Calle J,Condon KW,Maycas M,Zhang H,Carlesso N,Taketo M,Burr DB,Plotkin LI,Bellido T.
04Ene 2015
endocrine society

J Clin Endocrinol Metab. 2015 Jan;100(1):90-9. doi: 10.1210/jc.2014-2646.

Reference intervals for BTMs in older men have been defined. tOC may be more informative for hip fracture risk in older men than CTX-I and PINP. Further studies are needed to clarify the utility of BTM reference intervals in the management of aging men at risk of osteoporosis.

Autor: Chubb SA,Byrnes E,Manning L,Beilby JP,Ebeling PR,Vasikaran SD,Golledge J,Flicker L,Yeap BB.
04Ene 2015

J Bone Miner Res. 2015 Jan;30(1):3-23. doi: 10.1002/jbmr.2405.

Prevention strategies for ONJ include elimination or stabilization of oral disease prior to initiation of antiresorptive agents, as well as maintenance of good oral hygiene. In those patients at high risk for the development of ONJ, including cancer patients receiving high-dose BP or Dmab therapy, consideration should be given to withholding antiresorptive therapy following extensive oral surgery until the surgical site heals with mature mucosal coverage. Management of ONJ is based on the stage of the disease, size of the lesions, and the presence of contributing drug therapy and comorbidity. Conservative therapy includes topical antibiotic oral rinses and systemic antibiotic therapy. Localized surgical debridement is indicated in advanced non responsive disease and has been successful. Early data have suggested enhanced osseous wound healing with teriparatide in those without contraindications for its use. Experimental therapy includes bone marrow stem cell intralesional transplantation, low-level laser therapy, local platelet-derived growth factor application, hyperbaric oxygen, and tissue grafting.

Autor: Khan AA, Morrison A, Hanley DA, Felsenberg D, McCauley LK, O’Ryan F,ET AL.
04Ene 2015

FASEB J. 2015 Jan 28. pii: fj.14-259085. [Epub ahead of print]

In summary, our findings demonstrate that EPO negatively regulates bone mass and thus bears significant clinical implications for the potential management of patients with endogenously or therapeutically elevated EPO levels.

Autor: Hiram S,Liron T,Desher N,Mittelman M,Gassmann M,Rauner M,Franke K,Wielockx B,Neumann D,Gabet