04Sep 2015

Endocrinol Metab Clin North Am. 2015;44:517-30.

Osteoporosis is characterized by low bone mass and microarchitectural deterioration of bone tissue leading to decreased bone strength and an increased risk of low-energy fractures. Central dual-energy X-ray absorptiometry measurements are the gold standard for determining bone mineral density. Bone loss is an inevitable consequence of the decrease in estrogen levels during and following menopause, but additional risk factors for bone loss can also contribute to osteoporosis in older women. A well-balanced diet, exercise, and smoking cessation are key to maintaining bone health as women age. Pharmacologic agents should be recommended in patients at high risk for fracture.

Autor: Lupsa BC, Insogna K
04Sep 2015
MPubmed

J Bone Miner Res. 2015 Sep;30(9):1551-2. doi: 10.1002/jbmr.2601.

The study emphasized that remaining life expectancy is substantial: 13 years for men aged 60 years and 22 years for women aged 60 years. The substantial life expectancy following a fracture exposes patients to increased risk of refracture, which is itself associated with  elevated mortality risk. This underscores the need for evidence of sustained antifracture efficacy, a challenge facing us in the coming years.

Autor: Nguyen TV, Seeman E .
04Sep 2015
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PLoS One. 2015 Sep 8;10(9):e0136968. doi: 10.1371/journal.pone.0136968. eCollection 2015.

Frailty and pre-frailty, in Taiwan, was closely associated with recent falls, history of hip fractures and osteoporosis among community-dwelling people 50 years of age and older. Furthermore, frailty intervention programs should take an integrated approach towards strengthening both and muscle mass, as well as prevention of falls.

Autor: Liu LK, Lee WJ, Chen LY, Hwang AC, Lin MH, Peng LN, Chen LK.
04Sep 2015
endocrine society

J Clin Endocrinol Metab. 2015 Sep 14:jc20152568. [Epub ahead of print]

CONCLUSIONS: Lumbar spine and femoral neck BMD were associated with incident wrist fracture, but the FRAX threshold recommended to identify screening candidates did not identify the majority of women who subsequently experienced wrist fracture. Improved understanding of determinants of wrist fractures is warranted.

Autor: Crandall CJ, Hovey KM, Andrews CA, Cauley JA, Manson JE, Wactawski-Wende J, Wright NC, Li W, Beavers K, Curtis JR, LeBoff MS.
04Ago 2015
Springer

Curr Osteoporos Rep. 2015 Aug;13(4):193-7. doi: 10.1007/s11914-015-0269-9.

The study of bones has attracted researchers from many medical fields. To understand bone-organ interactions, hematologists were challenged to investigate bone marrow (BM), the core of bone where hematopoiesis takes place. Through studies of the hematopoietic stem cells niche, hematologists contributed to the discovery of unexpected functions of bone-forming osteoblasts and bone-buried osteocytes. In particular, the recent findings about osteocytes, as the regulatory system of lympho-hematopoiesis and fat metabolism, highlighted the central role of skeletal tissue in inter-organ communication. The cross-cutting consideration including hematology and many other fields will expand the bone research.

Autor: Sato M, Katayama Y.
04Ago 2015
Springer

Calcif Tissue Int. 2015 Aug;97(2):101-3. doi: 10.1007/s00223-015-0021-6. Epub 2015 Jun 13.

Bisphosphonates are extensively used for treatment of children and adults with osteogenesis imperfecta. Over years, studies have reported the response of BP treatment in individuals with OI but some questions remain still unanswered.

Autor: Brizola E, Shapiro JR.
04Ago 2015
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PLoS One. 2015 Aug 27;10(8):e0132146. doi: 10.1371/journal.pone.0132146. eCollection 2015.

CONCLUSION: A fracture liaison nurse in primary care has been associated with a period of improved management. Liaison nurses based in different parts of the health system should be tested in a prospective trial

Autor: Chant T, de Lusignan S, Cooper A, Elliott M, et al
04Ago 2015
MPubmed

J Bone Miner Res. 2015 Aug;30(8):1377-85. doi: 10.1002/jbmr.2467. Epub 2015 May 21.

In conclusion, FCA decreased dramatically after RYGB, even with most 25OHD levels ≥30 ng/mL and with recommended Ca intake. RYGB patients may need high Ca intake to prevent perturbations in Ca homeostasis, although the approach to Ca supplementation needs further study. Decline in FCA could contribute to the decline in BMD after RYGB, and strategies to avoid long-term skeletal consequences should be investigated.

Autor: Schafer AL, Weaver CM, Black DM, Wheeler AL, Chang H, Szefc GV, Stewart L, Rogers SJ, Carter JT, Posselt AM, Shoback DM, Sellmeyer DE.
04Jul 2015
endocrine society

. J Clin Endocrinol Metab. 2015 Jul;100(7):2784-2792. Epub 2015 May 8

Denosumab allows for supra-physiologic doses of calcitriol resulting in decreased parathyroid secretion and parathyroid hyperplasia. Supervised administration and weekly laboratory and clinical monitoring of serum calcium are recommended during the first month to prevent hypocalcemia

Autor: Chen CL, Chen NC, Liang HL, Hsu CY, Chou KJ, Fang HC, Lee PT