04Mar 2015
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J Bone Miner Res. 2015 Mar;30(3):488-97-

Using different osteotropic human prostate cancer cell lines, the influence of WNT5A overexpression and knock-down on proliferation, migration, and apoptosis was assessed. In vitro, WNT5A overexpression induced prostate cancer cell apoptosis and reduced proliferation and migration, whereas WNT5A knock-down showed opposite effects. In vivo, different xenograft models were used to determine the effects of WNT5A on tumor growth. Local tumor growth and tumor growth in the bone microenvironment was considerably diminished after WNT5A overexpression in PC3 cells. WNT5A exhibits antitumor effects in prostate cancer cells and may be suitable as a prognostic marker and therapeutic target for prostate cancer and associated skeletal metastases.

Autor: Thiele S1, Göbel A, Rachner TD, Fuessel S, Froehner M, Muders MH, Baretton GB, Bernhardt R, Jakob F, Glüer CC, Bornhäuser M, Rauner M, Hofbauer LC.
04Mar 2015
Springer

Calcif Tissue Int (2015) 96:500–509 DOI 10.1007/s00223-015-9980-x

They have demonstrated that lumbar spine texture analysis using TBS is a risk factor for osteoporotic fracture and also for risk of death. The predictive ability of TBS is independent of FRAX clinical risk factors and femoral neck BMD; finally we have derived an algorithm to adjust probability of fracture from clinical risk factors and BMD to account for TBS, an approach that will require validation in further independent cohorts.

Autor: McCloskey EV, Odén A, Harvey NC, Leslie WD, Hans D, Johansson H, Kanis JA.
04Feb 2015
Springer

Osteoporos Int. 2015 Feb;26(2):431-41. doi: 10.1007/s00198-014-2903-2. Epub 2014 Sep 30.

Early administration of BPs after surgery did not appear to delay fracture healing time either radiologically or clinically. Furthermore, according to the changes in BMD and bone turnover markers, the anti-resorptive efficacy of BPs given immediately after surgical repair should positively affect the rate of subsequent fractures.

Autor: Li YT, Cai HF, Zhang ZL.
04Feb 2015
Springer

Osteoporos Int. 2015 Feb;26(2):645-52. doi: 10.1007/s00198-014-2919-7.

Hip fracture is independently associated with increased risk of developing stroke. In addition, the risk of stroke following incidence of hip fracture is more prominent in younger patients, men, those with cardiovascular comor- bidities, and in patients using specific medication, such as diuretics and ABRs. Given the subsequent higher risk of stroke among patients with hip fracture, our study results indicate that physicians should be proactive to prevent strokes.

Autor: Tsai CH, Lin CL, Hsu HC, Chung WS
04Feb 2015
Springer

Osteoporos Int. 2015 Feb;26(2):449-58. doi: 10.1007/s00198-014-2813-3

The meta-analysis indicates that BMD is low in predialysis and dialysis patients with fractures. These findings, considered together with the recent prospective study in CKD, and post hoc analyses of the pivotal fracture trials suggests that BMD may be clinically useful in assessing fracture risk in CKD, different than what has been suggested in the KDIGO guidelines .

Autor: Bucur RC, Panjwani DD, Turner L, Rader T, West SL, Jamal SA.