05Jul 2014
Springer

Osteoporos Int. 2014 Nov;25(11):2609-15. doi: 10.1007/s00198-014-2801-7. Epub 2014 Jul 29.

The study demonstrates that mild or wedged vertebral shape changes are rare among younger subjects, suggesting that when these radiographic abnormalities are seen among older adults, they are less likely to be due to normal variation in vertebral body shape or congenital deformities. In light of previously described associations between mild or wedge vertebral shape changes and low BMD, our findings support current recommendations to treat mild wedged vertebral changes as osteoporosis or at least to consider it as a risk factor for osteoporotic fracture.

Autor: YU W, LIN Q, ZHOU X, SHAO H, SUN P.
05Jul 2014
Springer

Osteoporos Int 2014; Oct;25(10):2453-63. doi: 10.1007/s00198-014-2779-1. Epub 2014 Jul 16

The combination of cytokines present in serum of RA patients with active disease might contribute to bone loss by directly inhibiting osteoblast proliferation and differentiation, but especially by enhancing endogenous cyto- kine (i.e., RANKL and IL-6) production by osteoblasts, there- by stimulating osteoclastogenesis.

Autor: Pathak J L, Bravenboer N, Verschueren P , Lems WF, Luyten F P, Klein-Nulend J, Bakker A D.
05Jul 2014
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J Bone Miner Res. 2014; 29: 1715‒1717. doi: 10.1002/jbmr.2175.

In conclusion, this study profiled serum miRNAs in osteoporosis and identified 9 miRNAs highly associated with osteoporosis in blood serum. In bone tissue, 6 differentially expressed miRNAs were detectable. Five of these were simultaneously upregulated in the serum samples. Those 5 identified, significantly upregulated circulating miRNAs may provide novel biomarkers for osteoporosis and may play an important role in the pathogenesis of osteoporosisrelated hip fractures

Autor: Seeliger C*, Karpinski K , Haug A , Vester H , Schmitt A , Bauer JA and van Griensven M
05Jul 2014
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J Bone Miner Res. 2014 Aug;29(8):1745-55. doi: 10.1002/jbmr.2218.

Data presented here show close parallels between rising rates of urbanization and hip fractures across disparate geographic locations and cultures. Once the proportion of the urban population stabilized, hip fracture rates also stabilize or begin to decrease perhaps due to the influence of other factors such as birth cohort effects, changes in bone mineral density and BMI, osteoporosis medication use and/or lifestyle interventions such as smoking cessation, improvement in nutritional status and fall prevention.

Autor: Ballane G, Cauley JA, Luckey MM, Fuleihan Gel-H.
04Jul 2014
Springer

Osteoporosis International 2014; 25: 2685-2700. doi: 10.1002/biof.1186.

The osteocyte network plays a central role in directing bone response either to mechanical loading, or to unloading, leading correspondingly to bone formation or resorption. This review shows a key role of the osteocyte-produced sclerostin as a major mediator of the molecular mechanisms involved in the process of adaptive bone remodeling.

Autor: Sapir-Koren R, Livshits G.
05Jun 2014
Springer

Osteoporos Int (2014) 25:2271–2277. doi: 10.1007/s00198-014-2761-y. Epub 2014 Jun 21.

Lumbar spine texture analysis using TBS is a risk factor for major osteoporotic fractures and a risk factor for death. Lumbar spine TBS is able to predict incident major osteoporotic fractures independent of FRAX clinical risk factors and femoral neck BMD even after accounting for the increased death hazard.

Autor: Leslie WD, Johansson H, Kanis JA, Lamy O, Oden A, McCloskey E
05Jun 2014
Springer

Calcif Tissue Int. 2014 Sep;95(3):201-8. doi: 10.1007/s00223-014-9882-3. Epub 2014 Jun 20.

After adjusting for age, weight, BMD, smoking, and maternal and family history of fracture, TBS (but not BMD) remained a significant predictor of fracture: OR 1.28[1.13–1.46] even after adjustment. In a US female population, TBS again was able to discriminate between those with and those without fractures, even after adjusting for other clinical risk factors.

Autor: Leib E, Winzenrieth R, Lamy O, Hans D.
04Jun 2014
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J Bone Miner Res. 2014 Jul;29(7):1507-18. doi: 10.1002/jbmr.2226.

Bariatric surgery is a popular and effective treatment for severe obesity but may have negative effects on the skeleton. This review summarizes changes in bone density and bone metabolism from animal and clinical studies of bariatric surgery, with specific attention to Roux-en-Y gastric bypass (RYGB), adjustable gastric banding (AGB), and sleeve gastrectomy (SG). Skeletal imaging artifacts from obesity and weight loss are also considered. Despite challenges in bone density imaging, the preponderance of evidence suggests that bariatric surgery procedures have negative skeletal effects that persist beyond the first year of surgery, and that these effects vary by surgical type. The long-term clinical implications and current clinical recommendations are presented. Further study is required to determine mechanisms of bone loss after bariatric surgery. Although early studies focused on calcium/vitamin D metabolism and mechanical unloading of the skeleton, it seems likely that surgically induced changes in the hormonal and metabolic profile may be responsible for the skeletal phenotypes observed after bariatric surgery.

Autor: Yu EW.
04Jun 2014

J Bone Miner Res 2014; 29:1651-1660.

The clinical and radiographic findings of adult patients with persistent hypophosphatasemia resemble those of the adult form of hypophosphatasia. Clinicians should take notice of persistent hypophosphatasemia, consider the diagnosis of hypophosphatasia, and be cautious when considering potent anti-remodeling therapy in these adults. This population warrants further evaluation.

Autor: McKiernan FO, Berg R, Fuehrer J.
04Jun 2014
Springer

Osteoporos Int. 2014 Jun 25(6):1697-708. doi: 10.1007/s00198-014-2676-7.

In conclusion, we found that diabetes patients have a different bone turnover than non-diabetes patients and the differences in bone turnover are enhanced at menopause. The results from this meta-analysis underscore the need to conduct more re- search within the assessment of fracture risk using bone markers in patients with diabetes. The methodological study conducted in this study showed that it is not likely that bone markers change configuration due to changes in blood glu- cose. Thus, other mechanisms, apart from possible assay variability, may influence the heterogeneity observed for bio- markers in this study

Autor: Starup-Linde J1, Eriksen SA, Lykkeboe S, Handberg A, Vestergaard PIn