20Ene 2017
MPubmed

Calcif Tissue Int. 2016 Dec 7Watch Full Movie Online Streaming Online and Download

The adipokine adiponectin affects multiple target tissues and plays important roles in glucose metabolism and whole-body energy homeostasis. Circulating adiponectin levels in obese people are lower than in non-obese, and increased serum adiponectin is associated with weight loss. Results of these studies are not entirely congruent, partly due to variation among experimental systems and partly due to the complex nature of adiponectin signaling, which involves a combination of multiple direct and indirect mechanisms.

 

Autor: Naot D, Musson DS, Cornish J

20Ene 2017
MPubmed

Curr Osteoporos Rep. 2016 Dec;14(6):320-326.

Diabetic patients have a higher fracture risk than expected by their bone mineral density (BMD). Poor bone quality is the most suitable and explainable cause for the elevated fracture risk in this population. Advanced glycation end products (AGEs), physically affect the properties of the bone material, one of a component of bone quality, through their accumulation in the bone collagen fibers.

 

Autor: Yamamoto M, Sugimoto T

13Dic 2016
MPubmed

J Bone Joint Surg Am. 2016 Nov 16;98(22):1868-1878.

Osteoporosis drugs might affect fracture-healing. We therefore studied the effects of teriparatide in comparison with risedronate on recovery after pertrochanteric hip fractures. Teriparatide was associated with less pain and a shorter time to complete the TUG test between 6 and 26 weeks compared with risedronate. Other fracture-recovery outcomes were similar. The results should be interpreted with caution as these were secondary end points.

Autor: Aspenberg P, Malouf J, Tarantino U, García-Hernández P, Corradini C, Overgaard S, Stepan JJ, Borris , Lespessailles E,Frihagen F, Papavasiliou K, Petto H, Caeiro JR, Marin F
13Dic 2016
NEJM

New England Journal of Medicine, November 10, 2016 Vol. 375 No. 19, p 1817-1820.J.E.

The claim that large proportions of North American and other populations are deficient in vitamin D is based on misinterpretation and misapplication of the Institute of Medicine reference values for nutrients — misunderstandings that can adversely affect patient care.

Autor: Manson, P.M. Brannon, C.J. Rosen, and C.L. Taylor.
13Dic 2016
MPubmed

J Cell Physiol. 2016 Nov 18. doi: 10.1002/jcp.25693.
This article reviews the current body of knowledge on regulation of Hcy mediated oxidative stress and its role in bone remodeling, vascular blood flow and progression of bone disease. This article is protected by copyright. All rights reserved.

Autor: Behera J, Bala J, Nuru M, Tyagi SC, Tyagi N

Watch Full Movie Online Streaming Online and Download

13Dic 2016
MPubmed

PUMBE – Calcif Tissue Int (2016). doi:10.1007/s00223-016-0203-x

Anti-diabetes medications are crucial for maintaining glucose control and for preventing micro- and macrovascular complications in diabetes. However, they may modulate fracture risk in diabetes in different ways. The purpose of this review is to provide a comprehensive overview of the effect of these medications on bone metabolism and the studies exploring the risk or lack thereof of these medications on bone loss and fragility fractures.

Autor: Chandran, M.

13Dic 2016
MPubmed

J Clin Endocrinol Metab. 2016 Nov;101(11):4125-4134

Specific serum miRNA profiles are strongly related to bone pathologies. Therefore miRNAs might be directly linked to bone tissue homeostasis. In particular, miR-29b-3p has previously been reported as regulator of osteogenic differentiation and could serve as a novel marker of bone turnover in osteoporotic patients as a member of a miRNA signature.

A set of 19 miRNAs was differentially regulated in all subjects with low-traumatic fractures. miRNAs were excellent discriminators of patients with fractures, regardless of age and gender.

Autor: R Kocijan, C Muschitz, E Geiger, S Skalicky, A Baierl, R Dormann, F Plachel, X Feichtinger, P Heimel, A Fahrleitner-Pammer, J Grillari, H Redl, H Resch and M Hackl

25Nov 2016
MPubmed

Osteoporos Int. 2016 Nov 25.

This meta-analysis assessed the efficacy of statins on the risk of fracture, bone mineral density (BMD), and the markers of bone metabolism by collecting data from 33 clinical trials. They found that statin treatment was associated with bone metabolism. And statins seemed to be more effective on male patients with osteoporosis.  Statin treatment may be associated with a decreased risk of overall fractures and hip fractures,an increased BMD at the total hip, BMD at the lumbar spine, and OC

Autor: An T, Hao J, Sun S, Li R, Yang M, Cheng G, Zou M
19Nov 2016
MPubmed

J Bone Miner Res. 2016 Nov 19. doi: 10.1002/jbmr.3039.

The American Society for Bone and Mineral Research and the United States National Osteoporosis Foundation (NOF) formed a working group to develop principles of goal-directed treatment and identify gaps that need to be filled to implement this approach. With goal-directed treatment, a treatment goal would first be established choice of treatment  determined by the probability of achieving that goal.

Autor: Cummings SR, Cosman F, Lewiecki EM, Schousboe JT, Bauer D, Black D, Brown T, Cheung AM, Cody K, Cooper C, Diez-Perez A,Eastell R, Hadji P, Hosoi T, De Beur SJ, Kagan R, Kiel DP(17), Reid I, Solomon DH, Randall S
11Nov 2016
MPubmed

J Bone Miner Res. 2016 Nov 11. doi: 10.1002/jbmr.3037.

Osteoporotic fracture increases the risk of premature mortality. Muscle weakness  is associated with both increased fracture risk and low BMD. However, the role of muscle strength in post-fracture mortality is not well understood. This study examines the change of muscle strength measured at quadriceps (QS) before and after fracture, and defines the relationship between muscle strength and post-fracture mortality.

Autor: Pham HM, Nguyen SC, Ho-Le TP, Center JR, Eisman JA, Nguyen TV.