13Dic 2016

PUMBE – Calcif Tissue Int (2016). doi:10.1007/s00223-016-0203-x

Anti-diabetes medications are crucial for maintaining glucose control and for preventing micro- and macrovascular complications in diabetes. However, they may modulate fracture risk in diabetes in different ways. The purpose of this review is to provide a comprehensive overview of the effect of these medications on bone metabolism and the studies exploring the risk or lack thereof of these medications on bone loss and fragility fractures.

Autor: Chandran, M.

13Dic 2016

J Clin Endocrinol Metab. 2016 Nov;101(11):4125-4134

Specific serum miRNA profiles are strongly related to bone pathologies. Therefore miRNAs might be directly linked to bone tissue homeostasis. In particular, miR-29b-3p has previously been reported as regulator of osteogenic differentiation and could serve as a novel marker of bone turnover in osteoporotic patients as a member of a miRNA signature.

A set of 19 miRNAs was differentially regulated in all subjects with low-traumatic fractures. miRNAs were excellent discriminators of patients with fractures, regardless of age and gender.

Autor: R Kocijan, C Muschitz, E Geiger, S Skalicky, A Baierl, R Dormann, F Plachel, X Feichtinger, P Heimel, A Fahrleitner-Pammer, J Grillari, H Redl, H Resch and M Hackl

25Nov 2016

Osteoporos Int. 2016 Nov 25.

This meta-analysis assessed the efficacy of statins on the risk of fracture, bone mineral density (BMD), and the markers of bone metabolism by collecting data from 33 clinical trials. They found that statin treatment was associated with bone metabolism. And statins seemed to be more effective on male patients with osteoporosis.  Statin treatment may be associated with a decreased risk of overall fractures and hip fractures,an increased BMD at the total hip, BMD at the lumbar spine, and OC

Autor: An T, Hao J, Sun S, Li R, Yang M, Cheng G, Zou M
19Nov 2016

J Bone Miner Res. 2016 Nov 19. doi: 10.1002/jbmr.3039.

The American Society for Bone and Mineral Research and the United States National Osteoporosis Foundation (NOF) formed a working group to develop principles of goal-directed treatment and identify gaps that need to be filled to implement this approach. With goal-directed treatment, a treatment goal would first be established choice of treatment  determined by the probability of achieving that goal.

Autor: Cummings SR, Cosman F, Lewiecki EM, Schousboe JT, Bauer D, Black D, Brown T, Cheung AM, Cody K, Cooper C, Diez-Perez A,Eastell R, Hadji P, Hosoi T, De Beur SJ, Kagan R, Kiel DP(17), Reid I, Solomon DH, Randall S
11Nov 2016

J Bone Miner Res. 2016 Nov 11. doi: 10.1002/jbmr.3037.

Osteoporotic fracture increases the risk of premature mortality. Muscle weakness  is associated with both increased fracture risk and low BMD. However, the role of muscle strength in post-fracture mortality is not well understood. This study examines the change of muscle strength measured at quadriceps (QS) before and after fracture, and defines the relationship between muscle strength and post-fracture mortality.

Autor: Pham HM, Nguyen SC, Ho-Le TP, Center JR, Eisman JA, Nguyen TV.
31Oct 2016

Osteoporos Int. 2016 Oct 31. [Epub ahead of print] DOI: 10.1007/s00198-016-3769-2 PMID: 27796445 [PubMed – as supplied by publisher]

In this review, the authors present the best evidence available regarding bone loss in RA patients. The more recent knowledge of the cytokines’ interplay in the inflamed synovial membrane and its close relation to osteoclast development and activation demonstrated that the persistence of inflammation enhanced bone turnover, leading to bone erosions and systemic bone loss. Early and “aggressive” treatments were reported to be more effective in rapidly achieving a low level of inflammation and halting the progressive loss of bone. Although several studies reported favorable actions of biologic therapies on bone protection, there are still unmet needs for studies regarding their actions on the risk of bone fractures in RA patients. They will be developed in the near future or they are probably underway at this time.

Autor: Zerbini CA, Clark P, Mendez-Sanchez L, Pereira RM, Messina OD, Uña CR, Adachi JD, Lems WF, Cooper C, Lane NE; IOF Chronic Inflammation and Bone Structure (CIBS) Working Group.
29Oct 2016

J Bone Miner Res 2016, 31: 1791–1802. doi: 10.1002/jbmr.2869 PubMed PMID: 27163932Watch Full Movie Online Streaming Online and Download

In the context of glucocorticoid excess, activation of Wnt/β-catenin signaling by Sost/sclerostin deficiency sustains bone integrity by opposing bone catabolism despite markedly reduced bone formation and increased apoptosis. This crosstalk between glucocorticoids and Wnt/β-catenin signaling could be exploited therapeutically to halt resorption and bone loss induced by glucocorticoids and to inhibit the exaggerated bone formation in diseases of unwanted hyperactivation of Wnt/β-catenin signaling.

Autor: Sato, A. Y., Cregor, M., Delgado-Calle, J., Condon, K. W., Allen, M. R., Peacock, M., Plotkin, L. I. and Bellido, T.
24Oct 2016

J Bone Miner Res 2016 DOI: 10.1002/jbmr.2979 PubMed PMID: 27542960 First published: 24 October 2016

In summary, although obese women (OB) had significantly greater total vitamin D stores than non-obese control (C), the relationship between serum 25OHD and fat vitamin D and the overall pattern of distribution of vitamin D between the omental and subcutaneous fat compartments was similar. Our data demonstrate that obese subjects have greater adipose stores of vitamin D. They support the hypotheses that the enlarged adipose mass in obese individuals serves as a reservoir for vitamin D and that the increased amount of vitamin D required to saturate this depot may predispose obese individuals to inadequate serum 25OHD.

Autor: Angela Carrelli, Mariana Bucovsky, Ronald Horst, Serge Cremers, Chengchen Zhang, Marc Bessler, Beth Schrope, John Evanko, Jody Blanco, Shonni J Silverberg and Emily M Stein
14Oct 2016

Curr Osteoporos Rep. 2016 Oct;14(5):187-98. doi: 10.1007/s11914-016-0319-y. DOI: 10.1007/s11914-016-0319-y PMID: 27623679 [PubMed – in process]

Cortical porosity is important because of its impact on bone material and mechanical properties as well as its role in the remodeling process. This review aims to provide an overview of what this level of porosity is, why it is important, and how it can be characterized by imaging. Moving beyond a ‘trabeculocentric’ view of bone loss holds the potential to improve diagnosis and monitoring of interventions. Furthermore, cortical porosity is intimately linked to the remodeling process, which underpins bone loss, and thus a larger potential exists to improve our fundamental understanding of bone health through imaging of both humans and animal models.

Autor: Cooper DM, Kawalilak CE, Harrison K, Johnston BD, Johnston JD.