Angels Martinez-Ferrer MD1, Jordi Blasco MD2, Josep L Carrasco3, Juan Macho PhD2, Luis San Román MD2, Antonio López Rueda MD2, Ana Monegal PhD1, Nuria Guañabens PhD4, Pilar Peris PhD4,

Abstract

We have recently observed an increased risk for vertebral fractures (VF) in a randomized controlled trial comparing the analgesic effect of vertebroplasty (VP) versus conservative treatment in symptomatic VF. The aim of the present study was to evaluate the risk factors related to the development of VF after VP in these patients.

We evaluated risk factors including age, gender, bone mineral density, the number, type and severity of vertebral deformities at baseline, the number of vertebral bodies treated, the presence and location of disk cement leakage, bone remodeling (determining bone turnover markers) and 25 hydroxyvitamin D (25OHD) levels at baseline in all patients.Twenty-nine radiologically new VF were observed in 17/57 patients undergoing VP, 72% adjacent to the VP. Patients developing VF after VP showed an increased prevalence of 25OHD deficiency (< 20 ng/ml) and higher PINP values. 25OHD levels < 20ng/ml was the principal factor related to the development of VF after VP in multivariate analysis (RR,15.47; 95% CI,2.99-79.86, P<0.0001), whereas age >80 years (RR,3.20;95%CI,1.70-6.03, P=0.0007) and glucocorticoid therapy (RR,3.64;95%CI,1.61-8.26,P=0.0055) constituted the principal factors in the overall study population. Increased risk of VF after VP was also associated with cement leakage into the inferior disk (RR,6.14;95%CI,1.65-22.78, P=0.044) and >1 vertebral body treated during VP (RR,4.19; 95% CI,1.03-34.3, P=0.044).

In conclusion, nearly 30% of patients with osteoporotic VF treated with VP had a new VF after the procedure. Age, especially over 80 years, the presence of inferior disk cement leakage after the procedure, the number of cemented vertebrae and low 25OHD serum levels were related to the development of new VF in these patients; the latter indicating the need to correct vitamin D deficiency prior to performing VP. © 2013 American Society for Bone and Mineral Research.

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