Serum from postmenopausal women treated with a by-product of olive-oil extraction process stimulates osteoblastogenesis and inhibits adipogenesis in human mesenchymal stem-cells (MSC).

Aging may enhance both oxidative stress and bone-marrow mesenchymal stem-cell (MSC) differentiation into adipocytes. That reduces osteoblastogenesis, thus favoring bone-mass loss and fracture, representing an important worldwide health-issue, mainly in countries with aging populations. Intake of antioxidant products may help to retain bone-mass density.

Exp Gerontol. 2017 Feb 3;90:71-78. doi: 10.1016/j.exger.2017.01.024.

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Casado-Díaz A, Túnez-Fiñana I, Mata-Granados JM, Ruiz-Méndez MV,Dorado G, Romero-Sánchez MC, Navarro-Valverde C, Quesada-Gómez JM.