08Abr 2014

The impact on the population of the different recommendations is enormous, varying from 17% to 80% of the population over 50 who would be tested

Although in men it seems that a clinical rationale exists between the presence of risk factors and the rates of BMD testing, this pattern does not seem to exist in women. One in 10 of the densitometric tests performed were inappropriate according to all the guidelines.

Autor: Hurtado I, Sanfélix-Gimeno G, Baixauli-Pérez C, Peiró S, Sanfélix-Genovés J.

08Abr 2014

The results suggest that deletions in the 6p25.1 locus may predispose to higher risk of fracture in a subset of populations of European origin;

larger and geographically restricted studies will be needed to confirm this regional association. This is a first step towards the evaluation of the role of rare CNVs in osteoporosis.

Autor: Oei L, Hsu YH, Styrkarsdottir U, Eussen BH, de Klein A, Peters MJ, Halldorsson B,…

08Abr 2014

The results highlight the PUFA metabolism differences between uninduced and induced MSC to differentiate into adipocytes and osteoblasts, besides the relevant role of the lipoxygenase gene expression in adipogenesis induction.

Autor: Casado-Díaz A, Ferreiro-Vera C, Priego-Capote F, Dorado G, Luque-de-Castro MD, Quesada-Gómez JM.

08Abr 2014

Gene candidate and genome-wide association studies have revealed tens of loci of susceptibility for osteoporosis.

The results underscore the significance of the LRP5 gene in bone metabolism and emphasize the significance of the replication of previous results in independent cohorts.

Autor: Panach L, Mifsut D, Tarín JJ, Cano A, García-Pérez MA.

08Abr 2014

Keeping in mind the premise “living longer, living better”, this commentary is the result of the thoughts, proposals and conclusions obtained after one year working in the framework of this network.

Osteoporosis is a worldwide disease with a very high prevalence in humans older than 50. The main clinical consequences are bone fractures, which often lead to patient disability or even death.

Autor: Arcos D, Boccaccini AR, Bohner M, Díez-Pérez A, Epple M, Gómez-Barrena E,…

08Abr 2014

After examining results for 10 different bone fracture sites, advanced age appeared the single best possibility for uniting several different sites, resulting in an empirically based composite fracture risk model.

Several fracture prediction models that combine fractures at different sites into a composite outcome are in current use. However, to the extent individual fracture sites have differing risk factor profiles, model discrimination is impaired.

Autor: Fitzgerald G, Compston JE, Chapurlat RD, Pfeilschifter J, Cooper C,

08Abr 2014

HIV infection is associated with an almost 3-fold increase in fracture risk compared to that of uninfected age and gender-matched uninfected patients.

HIV patients are also at an almost 9-fold higher risk of hip fracture.

Autor: Prieto-Alhambra D, Güerri-Fernández R, De Vries F, Lalmohamed A, Bazelier M,…

08Abr 2014

This review describes the most recent data on the effects of glucocorticoids on the Wnt signaling pathway, especially on their antagonists, sclerostin and Dkk-1.

Bone formation is suppressed in glucocorticoid-induced osteoporosis. One of the mechanisms by which glucocorticoids depress bone formation is through their effects on the Wnt/β-catenin signaling pathway, a critical regulator of osteoblastogenesis.

Autor: Guañabens N, Gifre L, Peris P.

08Abr 2014

Long-term adherence (five years) to diets that feature normal levels of calcium, low protein and low salt may reduce numbers of stone recurrences,

decrease oxaluria and calcium oxalate relative supersaturation indexes in people with idiopathic hypercalciuria who experience recurrent kidney stones.

Adherence to a low salt, normal calcium level diet for some months can reduce calciuria and oxaluria. However, the other dietary interventions examined did not demonstrate evidence of significant beneficial effects.No studies were found investigating the effect of dietary recommendations on other clinical complications or asymptomatic idiopathic hypercalciuria.

Autor: Escribano J, Balaguer A, Roqué i Figuls M, Feliu A, Ferre N.

08Abr 2014

In our study, postmenopausal women who live in rural populations have more poverty, lower values of vitamin D, lower BMD in the lumbar spine and a higher prevalence of vertebral fractures and of osteoporosis.

The higher prevalence of obesity, arterial hypertension and diabetes mellitus observed in these women may be adjuvant factors, all fostered by their socioeconomic state of poverty.

Autor: Gómez-de-Tejada Romero MJ, Navarro Rodríguez MD, Saavedra Santana P, Quesada Gómez JM, …