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Osteoporos Int. 2016 Jan;27(1):161-70. doi: 10.1007/s00198-015-3226-7. Epub 2015 Jul 16. Myostatin deficiency partially improved the reduced femoral bone biomechanical strength of adult +/oim mice by increasing muscle mass with concomitant improvements in bone microarchitecture and … Leer más

GQ-177, a new thiazolidinedione,  acts as a partial PPARγ agonist that improves obesity-associated insulin resistance and dyslipidemia with atheroprotective effects in LDLr-/- mice.

A deeper knowledge of the mechanisms involved in chondrocyte aging could identify potential targets for the treatment of OA, a prevalent and therapeutic-orphan disease.

The beneficial effects of exercise on bone metabolism depends on the intermittent exposure to myokines which, instead, act as inflammatory/pro-resorptive mediators when chronically elevated; on the other hand, the reduction in the circulating levels of … Leer más

Both cortical and trabecular vBMD are reduced at the proximal femur in ACRO patients, regardless of gender, gonadal status and disease activity. Disease duration is negatively associated with trabecular vBMD at the total hip and … Leer más

We identified two osteoblast miRNAs over-expressed in osteoporotic fractures, which opens novel prospects for research and therapy.

Taking together these results indicate for the first time that mesenchymal stem cells have significant differences in their proliferative, pluripotency and metabolism profiles and those differences are age depending.

No significant effect in TBS was observed in liver transplant patients treated with RIS or calcium and vitamin D3 after 1 year of follow-up. In these patients the clinical usefulness of this new tool should … Leer más

J Bone Miner Res. 2015 Dec;30 (12):2140-2149. doi: 10.1002/jbmr.2735. Epub 2018 Nov 4. Review. Collectively, this developing area of osteoimmunology raises new questions and promises to provide novel insights into pathophysiologic conditions as well as … Leer más