Osteoporos Int. 2015 Oct;26(10):2401-11. doi: 10.1007/s00198-015-3253-4. Epub 2015 Aug 18. These data from the Swedish Prescribed Drug Register and literature review suggest that persistence was higher with denosumab than with oral bisphosphonates. Autor: Karlsson L, … Leer más
Osteoporos Int. 2015 Oct;26(10):2479-89. doi: 10.1007/s00198-015-3164-4. Epub 2015 May 28. These data extend the real-world evidence regarding persistence with and adherence to denosumab, both of which are critical for favorable clinical outcomes, including fracture risk … Leer más
J Bone Miner Res. 2015 Oct;30(10):1747-53. doi: 10.1002/jbmr.2531. A position paper of the National Bone Health Alliance recently recommended that diagnostic criteria for osteoporosis be redefined. We review the merits and demerits of this proposal … Leer más
J Bone Miner Res. 2015 Oct;30(10):1758-66. doi: 10.1002/jbmr.2515. Epub 2015 May 10. In summary, for older men and women, calcium intakes of up to 1348 (316) mg/d from food were associated with decreased risks for … Leer más
rs1544410 polymorphisms do not account significantly for the changes in bone mass in Spanish women with osteoporosis undergoing treatment.
DM worsens bone alterations of aged mice, related to decreased bone turnover and bone vasculature and increased senescence, independently of the anti-oxidative stress machinery.
We identified a low-frequency non-coding variant near a novel locus, EN1, with an effect size fourfold larger than the mean of previously reported common variants for lumbar spine BMD (rs11692564) which was also associated with … Leer más
Sclerostin and estradiol levels are associated with the response to bisphosphonate therapy in women with postmenopausal osteoporosis.
In this review, we discuss the current concepts about the cellular and molecular mechanisms whereby PTHrP may induce anabolic actions in bone. Pre-clinical studies and clinical data using N-terminal PTHrP analogs are also summarized, pointing … Leer más
Most of the 13 tools are feasible in clinical practice. FRAX has the largest number of externally validated and independent studies. The overall accuracy of the different tools is satisfactory (>0.70), with QFracture reaching 0.89 … Leer más
