CathepsinKCre mediated deletion of βcatenin results in dramatic loss of bone mass by targeting both osteoclasts and osteoblastic cells

Sci Rep. 2016 Nov 2;6:36201. doi: 10.1038/srep36201

This study examines the effects of Wnt/βcatenin signaling in mature osteoclasts by generating mice lacking βcatenin in CathepsinK-expressing cells (Ctnnb1(f/f);CtsKCre mice). Their results indicate that the bone phenotype of Ctnnb1(f/f);CtsKCre animals combines a cell-autonomous effect in the mature osteoclast with indirect effects  due to the additional targeting of osteoblastic cells.

Autor: Ruiz P, Martin-Millan M, Gonzalez-Martin MC, Almeida M,González-Macias J, Ros MA