IMPACT OF ESTROGENS ON ATHEROSCLEROSIS AND BONE IN THE APOLIPOPROTEIN E-DEFICIENT MOUSE MODEL.

Endogenous estrogens partially reduce atherogenic burden in female apolipoprotein E-deficient mice. Ovariectomy increases bone resorption, but not under exacerbated proatherogenic conditions induced by high-fat diet. The absence of apolipoprotein E might have an influence on the asymmetric responses of atherogenesis and bone resorption.

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