Página 129 – SEIOMM, Sociedad Española de Investigación Ósea

BINDING KINETICS OF A FLUORESCENTLY LABELED BISPHOSPHONATE AS A TOOL FOR DYNAMIC MONITORING OF BONE MINERAL DEPOSITION IN VIVO

JBMR 2014; 29(9) 1993-2003 The results suggest monitoring binding kinetics based on fluorescently labeled bisphosphonates represents a highly sensitive, site-specific method for monitoring changes in bone mineral deposition with the potential for translation into human … Leer más

Mineralisation of collagen rich soft tissues and osteocyte lacunae in Enpp1−/− mice

Bone. 2014 Sep 28;69C:139-147. doi: 10.1016/j.bone.2014.09.016. [Epub ahead of print] This study examined the role of NPP1 in osteocytes, osteoclasts and cortical bone, using a mouse model lacking NPP1 (Enpp1−/−) he cortical bone from Enpp1−/− … Leer más

Association of chronic obstructive pulmonary disease and smoking status with bone density and vertebral fractures in male lung cancer screening participants

J Bone Miner Res. 2014 Oct;29(10):2224-9. doi: 10.1002/jbmr.2248. In conclusion, our study shows that lung cancer screening participants have a substantial vertebral fracture burden. Fractures are more common in current smokers, who also have lower … Leer más

Reproducibility of results in preclinical studies: a perspective from the bone field

J Bone Miner Res. 2014 Oct;29(10):2131-40. doi: 10.1002/jbmr.2293 In this invited perspective, we highlight the magnitude of the problem across biomedical fields and address the relevance of these concerns to the field of bone and … Leer más

Osteocyte-derived RANKL is a critical mediator of the increased bone resorption caused by dietary calcium deficiency

Bone 2014;66:147-154 The results demonstrate that RANKL produced by osteocytes contributes to the increased bone resorption and the bone loss caused by secondary hyperparathyroidism, strengthening the evidence that osteocytes are an important target cell for … Leer más

The fracture sites of atypical femoral fractures are associated with the weight-bearing lower limb alignment

Bone. 2014 Jun 14;66C:105-110. doi: 10.1016/j.bone.2014.06.008. [Epub ahead of print]. The femorotibial angle (FTA) of the patients with atypical diaphyseal femoral fracture were significantly larger compared to that of those with not only atypical subtrochanteric … Leer más

Prevalence and predictors of low bone density and fragility fractures in women with systemic lupus erythematosus in a Mediterranean region.

Fragility fractures were seen in 4.4 % of SLE patients. All patients with fragility fractures showed osteopenia at BMD. There is a high prevalence of bone loss in SLE patients, since up to 46 % … Leer más

Spanish Menopause Society position statement: Use of denosumab in postmenopausal women.

A panel of experts from the Spanish Menopause Society has met to develop usage recommendations based on the best available evidence.

The Association between Nutritional Screening Via The Conut Index And Bone Mineral Density In Chronic Liver Disease of Various Etiologies.

Malnutrition assessed by CONUT was very frequent in patients with liver cirrhosis. CONUT score inversely correlated with liver function, while malnutrition stage directly correlated with BMD, fracture risk, and 25(OH)-D3. Total cholesterol showed a negative … Leer más

Effect of lysophosphatidic acid receptor inhibition on bone changes in ovariectomized mice.

Pharmacological inhibition of lysophosphatidic acid receptorwas not beneficial for preventing bone loss in ovariectomized mice, indicating that its favorable effect on bone remodeling is less general than hypothesized.

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