THE OSTEOBLAST TO OSTEOCYTE TRANSITION: EPIGENETIC CHANGES AND RESPONSE TO THE VITAMIN D3 HORMONE

Mol Endocrinol. 2014 Jul;28(7):1150-65

We conclude that osteocytogenesis is accompanied by changes in gene expression that may be driven by both genetic and epigenetic components. These changes are likely responsible for the osteocyte phenotype and may contribute to reduced sensitivity to 1,25(OH)(2)D(3).

Autor: St John HC, Bishop KA, Meyer MB, Benkusky NA, Leng N, Kendziorski C, Bonewald LF, Pike JW.
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