Monthly Archives: diciembre 2013

Calcified Tissue International (2014) 94:4: 423-432 They conclude that Cnr2 deficiency affects expression of a large number of genes in different strains of mice, and that these differences are likely to be responsible in part for the differences in skeletal phenotype that they and others have observed in mice with defective cannabinoid receptor signalling in […]

Osteoporos Int (2014) 25:1267–1274. DOI 10.1007/s00198-013-2586-0. Conclusions This study supports other international studies by showing changes in the incidence of hip fractures after age population adjustment, which denotes a decrease in the younger age groups and among women and shows an increase in both groups over 85 years. The increase in the crude incidence rate […]

In conclusion, our data highlight the potential for novel drug targeting approaches in rare skeletal disorders ranging from severe skeletal fragility to sclerosing bone overgrowth through selective modulation of canonical WNT signaling. These approaches should also be beneficial in the context of other medical conditions with much less severe phenotypes, such as postmenopausal osteoporosis, given […]