Replication study of three functional polymorphisms associated with bone mineral density in a cohort of Spanish women.

Gene candidate and genome-wide association studies have revealed tens of loci of susceptibility for osteoporosis.

The results underscore the significance of the LRP5 gene in bone metabolism and emphasize the significance of the replication of previous results in independent cohorts.

Autor: Panach L, Mifsut D, Tarín JJ, Cano A, García-Pérez MA.