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Nature. 2014 Feb 13;506(7487):240-4. doi: 10.1038/nature12883. Epub 2014 Jan 15 These findings demonstrate that genetic alterations in osteoblasts can induce acute myeloid leukaemia, identify molecular signals leading to this transformation and suggest a potential novel … Leer más

In conclusion, our study does not support the hypothesis that calcium supplementation increases either carotid artery intimal medial thickness or carotid atherosclerosis. In addition, calcium supplementation and high total calcium intake may indeed reduce carotid … Leer más

In conclusion, despite the huge impact of osteoporosis worldwide, our knowledge of bone genetics and biology remains remarkably incomplete. Our findings and models provide compelling genetic evidence of a novel molecular network regulating adult skeletal … Leer más

The trabecular bone score (TBS) is a gray‐level textural metric that can be extracted from the two‐dimensional lumbar spine dual‐energy X‐ray absorptiometry (DXA) image. TBS is related to bone microarchitecture and provides skeletal information that … Leer más

J Clin Invest. 2014 Apr 1;124(4):1-13. doi: 10.1172/JCI72323. Epub 2014 Mar 18. Together, these results underscore the involvement of bone, among other tissues, in the disruption of whole-body glucose homeostasis resulting from a HFD and … Leer más

In conclusion, our data highlight the potential for novel drug targeting approaches in rare skeletal disorders ranging from severe skeletal fragility to sclerosing bone overgrowth through selective modulation of canonical WNT signaling. These approaches should … Leer más

The results of this nested case–control study in the CPRD indicate no evidence for a higher risk of MI or cardiovascular death associated with the use of strontium ranelate in women treated for osteoporosis compared … Leer más

Osteoporos Int (2014) 25:1267–1274. DOI 10.1007/s00198-013-2586-0. Conclusions This study supports other international studies by showing changes in the incidence of hip fractures after age population adjustment, which denotes a decrease in the younger age groups … Leer más

Calcified Tissue International (2014) 94:4: 423-432 They conclude that Cnr2 deficiency affects expression of a large number of genes in different strains of mice, and that these differences are likely to be responsible in part … Leer más