Osteoporosis has become an emerging comorbid condition in people living with HIV (PLWH). The increase in survival and the progressive aging of PLWH will make this complication more frequent in the near future. In addition … Leer más
Denosumab, a monoclonal antibody to the receptor activator of nuclear factor-κB ligand (RANKL), might be a novel preventative therapy for BRCA1-mutation carriers at high risk of developing breast cancer. They propose that breast epithelium-specific mono-allelic … Leer más
Periostin is an extracellular matrix protein, and in bone is expressed most highly in the periosteum. It increases bone formation through osteoblast differentiation, cell adhesion, Wnt signalling and collagen cross-linking. We hypothesised that serum periostin … Leer más
Bone has recently emerged as a pleiotropic endocrine organ that secretes at least two hormones, FGF23 and osteocalcin, which regulate kidney function and glucose homeostasis, respectively. These findings have raised the question of whether other … Leer más
This study has as objectives: To estimate the preferences of osteoporotic patients for medication attributes, and analyse data from seven European countries. In total, 1124 patients completed the experiment, with a sample of between 98 … Leer más
HIV infection has been associated with reduced bone mineral density (BMD). Antiretroviral therapy has a deleterious effect on BMD, but its effect on bone fragility is not clear. Long-term treatment with TDF-FTC leads to impaired … Leer más
This meta-analysis aims to determine the effects of regular swimming on bone mineral density (BMD) in young adults (18-30 years). Young adult swimmers present similar BMD values than CG and lower values than HIGH. J … Leer más
Ti-based alloys have increased importance for biomedical applications due to their excellent properties. In particular, the two recently developed TiZrPdSi(Nb) alloys, with a predominant β-Ti phase microstructure, have good mechanical properties, such as a relatively … Leer más
The skeleton is the most common site of colonization by metastatic cancers. Zoledronic acid (ZA) has been shown to be effective for the treatment of bone metastases regardless of whether the bone lesions are osteolytic … Leer más
Bariatric surgery is one of the most common surgeries within developed countries due to the increase in morbid obesity that has been observed in the past decades.The short-term alterations in the metabolism of calcium and … Leer más
