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Molecular gates in mesoporous bioactive glasses for the treatment of bone tumors and infection.
Mesoporous bioactive glasses are recently gaining importance thanks to their bone regenerative properties.Moreover, the mesoporous nature of these materials makes them suitable for drug delivery applications, opening new lines in the field of bone therapies. … Leer más
Lithogenic factors in postmenopausal women with osteoporotic fracture.
The aim of this study was to show the presence of phosphorus and calcium metabolism disorders and the presence of urine lithogenic factors in women with osteoporotic fracture without previous urinary lithiasis. A cross-sectional study … Leer más
Generation and characterization of two immortalized human osteoblastic cell lines useful for epigenetic studies.
Different model systems using osteoblastic cell lines have been developed to help understand the process of bone formation. Here, we report the establishment of two human osteoblastic cell lines obtained from primary cultures upon transduction … Leer más
BRCA1 haploinsufficiency cell-autonomously activates RANKL expression and generates denosumab-responsive breast cancer-initiating cells.
Denosumab, a monoclonal antibody to the receptor activator of nuclear factor-κB ligand (RANKL), might be a novel preventative therapy for BRCA1-mutation carriers at high risk of developing breast cancer. They tested the alternative but not … Leer más
Trochanteric hip fracture during cardioversion therapy. A case report.
Trochanteric hip fractures in elderly patients with osteoporosis are commonly caused by low energy trauma. The cardioversion therapy is an extremely rare cause of this type of fracture.They report the case of a woman with … Leer más
Challenges of bone tissue engineering in orthopaedic patients.
Bone defects may impede normal biomechanics and the structural stability of bone as an organ. In many cases, the correction of bone defects requires extensive surgical intervention involving the use of bone-grafting techniques and other … Leer más
Age-Related Loss in Bone Mineral Density of Rats Fed Lifelong on a Fish Oil-Based Diet Is Avoided by Coenzyme Q10 Addition.
Oxidative stress has been related to this bone loss, making dietary compounds with antioxidant properties a promising weapon. Male Wistar rats were maintained on diets with fish oil as unique fat source, supplemented or not … Leer más
Effect of vanadium on calcium homeostasis, osteopontin mRNA expression, and bone microarchitecture in diabetic rats.
The aim of this study was to examine whether alterations caused by diabetes in calcium homeostasis, expression of osteopontin and the microarchitecture of bone are corrected by exposure to vanadium. They conclude that treatment with … Leer más
