In this review, we discuss the current concepts about the cellular and molecular mechanisms whereby PTHrP may induce anabolic actions in bone. Pre-clinical studies and clinical data using N-terminal PTHrP analogs are also summarized, pointing … Leer más
Most of the 13 tools are feasible in clinical practice. FRAX has the largest number of externally validated and independent studies. The overall accuracy of the different tools is satisfactory (>0.70), with QFracture reaching 0.89 … Leer más
Several miRNAs may be biomarkers of bone fracture, particularly miR-21-5p.
The results of this pilot study suggest that these fractures are polygenic and are associated with the accumulation of changes in the coding regions of several genes.
The BsmI polymorphism in the VDR gene was not associated with BMD in Spanish postmenopausal women.
The main objective of the review is to find out indications for surgery, outcomes of these patients and also the standard perioperative management.
J Bone Miner Res. 2015 Aug;30(8):1377-85. doi: 10.1002/jbmr.2467. Epub 2015 May 21. In conclusion, FCA decreased dramatically after RYGB, even with most 25OHD levels ≥30 ng/mL and with recommended Ca intake. RYGB patients may need high … Leer más
PLoS One. 2015 Aug 27;10(8):e0132146. doi: 10.1371/journal.pone.0132146. eCollection 2015. CONCLUSION: A fracture liaison nurse in primary care has been associated with a period of improved management. Liaison nurses based in different parts of the health … Leer más
Calcif Tissue Int. 2015 Aug;97(2):101-3. doi: 10.1007/s00223-015-0021-6. Epub 2015 Jun 13. Bisphosphonates are extensively used for treatment of children and adults with osteogenesis imperfecta. Over years, studies have reported the response of BP treatment in … Leer más
Curr Osteoporos Rep. 2015 Aug;13(4):193-7. doi: 10.1007/s11914-015-0269-9. The study of bones has attracted researchers from many medical fields. To understand bone-organ interactions, hematologists were challenged to investigate bone marrow (BM), the core of bone where … Leer más
