Serum Circulating MicroRNAs as Biomarkers of Osteoporotic Fracture
Several miRNAs may be biomarkers of bone fracture, particularly miR-21-5p.
Exon array analysis reveals genetic heterogeneity in atypical femoral fractures. A pilot study
The results of this pilot study suggest that these fractures are polygenic and are associated with the accumulation of changes in the coding regions of several genes.
Lack of association of vitamin D receptor BsmI gene polymorphism with bone mineral density in Spanish postmenopausal women
The BsmI polymorphism in the VDR gene was not associated with BMD in Spanish postmenopausal women.
Surgical treatment in spine Paget’s disease: a systematic review
The main objective of the review is to find out indications for surgery, outcomes of these patients and also the standard perioperative management.
Intestinal Calcium Absorption Decreases Dramatically After Gastric Bypass Surgery Despite Optimization of Vitamin D Status
J Bone Miner Res. 2015 Aug;30(8):1377-85. doi: 10.1002/jbmr.2467. Epub 2015 May 21. In conclusion, FCA decreased dramatically after RYGB, even with most 25OHD levels ≥30 ng/mL and with recommended Ca intake. RYGB patients may need high … Leer más
Serum 25-Hydroxyvitamin D Levels: Variability, Knowledge Gaps, and the Concept of a Desirable Range
J Bone Miner Res. 2015 Jul;30(7):1119-33. doi: 10.1002/jbmr.2536. Epub 2015 May 7. We propose a desirable range of 20 to 40 ng/mL (50 to 100 nmol/L), provided precise and accurate assays are used. Although slightly lower levels, … Leer más
Effects of Denosumab and Calcitriol on Severe Secondary Hyperparathyroidism in Dialysis Patients With Low Bone Mass
. J Clin Endocrinol Metab. 2015 Jul;100(7):2784-2792. Epub 2015 May 8 Denosumab allows for supra-physiologic doses of calcitriol resulting in decreased parathyroid secretion and parathyroid hyperplasia. Supervised administration and weekly laboratory and clinical monitoring of … Leer más
Oral Calcidiol Is More Effective Than Cholecalciferol Supplementation to Reach Adequate 25(OH)D Levels in Patients with Autoimmune Diseases Chronically Treated with Low Doses of Glucocorticoids: A «Real-Life» Study
Patients with higher body mass index and those receiving higher doses of glucocorticoids are at increased risk of having lower levels of 25(OH)D. In these patients, calcidiol supplementations are more effective than cholecalciferol to reach … Leer más
CYP11A1 expression in bone is associated with aromatase inhibitor-related bone loss.
The genetic association of CYP11A1 gene with AIBL and its expression in bone tissue reveals a potential local function of this enzyme in bone metabolism regulation, offering a new vision of the steroidogenic ability of … Leer más
Risks and Benefits of Bisphosphonate Therapies
The aims of this review is to compile the basic characteristics of these drugs and outline the most important benefits and side effects and provide a clinical context as well as a research agenda to … Leer más
