J Bone Miner Res. 2015 May;30(5):753-64. doi: 10.1002/jbmr.2496. Combined therapy remains a potentially valuable approach to therapy. Because studies of antifracture efficacy comparing combined with single therapy are unlikely to be performed in humans, efforts … Leer más
Journal of Bone and Mineral Research 2015; Volume 30, Issue 6, pages 951–966 The goal of this review is to clarify the biomechanical mechanisms and to make recommendations for systematically evaluating phenotypic changes in mouse … Leer más
Journal of Bone and Mineral Research 2015; Volume 30, Issue 6, pages 970–975 The data show that hyponatremia is associated with up to a doubling in the risk of hip and morphometric spine fractures, independent … Leer más
Prescribed medicines and potentially inappropriate medicines (PIM) and potentially prescribing omissions (PPO) prevalence were high among patients 85 years and over. Benzodiazepine use in those who are prone to falls and omission of calcium and … Leer más
Bone. 2015 May 16. pii: S8756-3282(15)00195-7. doi: 10.1016/j.bone.2015.05.016. Although TBS changes with osteoporosis treatment, the magnitude is less than that of aBMD of the spine, and it is not clear how change in TBS relates … Leer más
DALY losses were considerable amongst postmenopausal women with osteoporosis. Not having a prior bone fracture, being older, using a SERM and having less osteoporotic risk factors were all linked to less DALY losses.
JAMA Intern Med. Published online April 13, 2015. doi:10.1001/jamainternmed.2015.0747. In this group of frail elderly women with osteoporosis, 1 dose of zoledronic acid improved BMD over 2 years. The clinical importance of nonsignificant increases in … Leer más
The switch from tenofovir to abacavir seems to induce a positive effect on bone tissue, since bone turnover markers decreased. In addition, circulating sclerostin levels increased, a change associated with improved bone properties.
JAMA. 2015 Apr 14;313(14):1467-1468. doi: 10.1001/jama.2015.1064. This JAMA Clinical Guidelines Synopsis article summarizes the most recent National Osteoporosis Foundation guidelines on screening older men and postmenopausal women for osteoporosis. Autor: Altkorn D, Cifu AS.
The tissue-selective estrogen complex (TSEC) combines bazedoxifene and conjugated estrogens and is designed not only to improve menopausal symptoms and vulvovaginal atrophy but also to prevent bone loss. Therefore, it maintains the benefits of estrogen … Leer más
