J Bone Miner Res. 2015 May;30(5):929-33. doi: 10.1002/jbmr.2410. We conclude that the effects of bisphosphonates on fracture prevention in osteogenesis imperfecta are inconclusive. Adequately powered trials with a fracture endpoint are needed to further investigate … Leer más
J Bone Miner Res. 2015 May;30(5):934-44. doi: 10.1002/jbmr.2442. The results suggest almost all patients who have received six annual ZOL infusions can stop medication for up to 3 years with apparent maintenance of benefits. Autor: … Leer más
JAMA Intern Med. Published online April 13, 2015. doi:10.1001/jamainternmed.2015.0747. In this group of frail elderly women with osteoporosis, 1 dose of zoledronic acid improved BMD over 2 years. The clinical importance of nonsignificant increases in … Leer más
J Clin Endocrinol Metab. 2015 Apr;100(4):1343-9. doi: 10.1210/jc.2014-4166. Epub 2015 Feb 2. Arterialized plasma HCO3 was associated positively with cross-sectional BMD and inversely with the rate of bone loss, implying that systemic acid-base status is … Leer más
J Clin Endocrinol Metab. 2015 Apr;100(4):1237-40. doi: 10.1210/jc.2015-1396 Autor: Magge SN.
The switch from tenofovir to abacavir seems to induce a positive effect on bone tissue, since bone turnover markers decreased. In addition, circulating sclerostin levels increased, a change associated with improved bone properties.
The tissue-selective estrogen complex (TSEC) combines bazedoxifene and conjugated estrogens and is designed not only to improve menopausal symptoms and vulvovaginal atrophy but also to prevent bone loss. Therefore, it maintains the benefits of estrogen … Leer más
Sequential antiresorptive therapy is recommended to maintain drug increases in bone mass and support secondary mineralization of the newly formed bone. Combination therapies of antiresorptives and anabolic agents have shown a significant increase in bone … Leer más
Our study is the first to demonstrate that reference point indentation is sensitive enough to reflect changes in cortical bone indentation following treatment with osteoporosis therapies in patients newly exposed to glucocorticoids.
J Clin Invest. 2015 Apr;125(4):1509-22. doi: 10.1172/JCI77716. Epub 2015 Mar 9. Together, our results indicate that miR-188 is a key regulator of the age-related switch between osteogenesis and adipogenesis of BMSCs and may represent a … Leer más
