In conclusion, administration of oral and intravenous bisphosphonates was associated with increased bone mineral density at the lumbar spine and total hip over two years in HIV-positive patients. However, none of the included trials were … Leer más
J Bone Miner Res. 2014 Dec;29(12):2545-51. doi: 10.1002/jbmr.2283 Percentage change from baseline in TH and FN BMD at months 12 and 24 was greater (p < 0.05) in ZOL-treated patients compared with placebo in most subgroups. Treatment-by-subgroup … Leer más
J Bone Miner Res. 2014 Dec;29(12):2529-33. doi: 10.1002/jbmr.2387. Accordingly, this Perspective provides evidence that the «undetermined significance» portion of the MGUS acronym may be best replaced in favor of the term «monoclonal gammopathy of skeletal … Leer más
Journal of Bone and Mineral Research, Vol. 29, No. 12, December 2014, pp 2537–2544. doi: 10.1002/jbmr.2309. The studies found that diffuse matrix damage regions in living cortical bone undergo a direct microstructural and mechanically effective … Leer más
Journal of Bone and Mineral Research, Volume 29, Issue 12, pages 2594–2600. doi: 10.1002/jbmr.2291. In conclusion, the estimated femoral strength from FE analysis of DXA scans is an independent predictor and performs at least as … Leer más
Bone 2014; 73:1-7. doi: 10.1016/j.bone.2014.12.003. Over time, two periods of increased PHPT incidence occurred, one beginning in 1974 (121.7 per 100,000 person-years) and a second peak (86.2 per 100,000 person-years) starting in 1998. The median age of … Leer más
JAMA. 2014 Dec 3;312(21):2285-6. doi: 10.1001/jama.2014.14038. Although the optimal rate of bisphosphonate use in men on androgen deprivation therapy (ADT) is unknown, it is reasonable that most men with prior osteoporosis or fracture should be … Leer más
In this first hypothesis-free study of the bone microRNome we found two miRNAs, miR-187, and miR-518f, differentially regulated in osteoporotic bone. Further studies are needed to elucidate the mechanisms involved in the association of these … Leer más
These reference data lay the ground to evaluate bone growth and metabolism in prepubertal children in epidemiological and clinical settings. They may also inform clinical practice to monitor skeletal development and to assess adverse drug … Leer más
An inverse correlation between IGF-1 levels and asymmetric dimethylarginine (ADMA), an endogenous endothelial nitric oxide synthase inhibitor that impairs nitric oxide production and secretion promoting endothelial dysfunction, was found. No significant association was found between … Leer más
