A New Role For 5-methoxytryptophol On Bone Cells Function In Vitro.
In conclusion, the present study demonstrates a new role of 5-methoxytryptophol inhibiting osteoclastogenesis and promoting osteoblast differentiation.
Relationship of Dickkopf1 (DKK1) with Cardiovascular Disease and Bone Metabolism in Caucasian Type 2 Diabetes Mellitus.
In summary, circulating DKK1 levels are higher in Type 2 Diabetes Mellitus with Cardiovascular Disease and are associated with an abnormal carotid intima media thickness in this cross-sectional study. DKK1 may be involved in vascular … Leer más
Analysis of the Bone MicroRNome in Osteoporotic Fractures.
In this first hypothesis-free study of the bone microRNome we found two miRNAs, miR-187, and miR-518f, differentially regulated in osteoporotic bone. Further studies are needed to elucidate the mechanisms involved in the association of these … Leer más
Reference values of bone stiffness index and C-terminal telopeptide in healthy European children.
These reference data lay the ground to evaluate bone growth and metabolism in prepubertal children in epidemiological and clinical settings. They may also inform clinical practice to monitor skeletal development and to assess adverse drug … Leer más
Gaucher disease and bone manifestations
Calcif Tissue Int. 2014 Dec;95(6):477-94. doi: 10.1007/s00223-014-9923-y We have conducted a systematic review of all the various aspects of Gaucher disease, focusing on different skeletal manifestations, pathophysiology of bone alterations, clinical symptoms, and current diagnostic … Leer más
Literature review: The effects of teriparatide therapy at the hip in patients with osteoporosis
Bone 67; 246–256. doi: 10.1016/j.bone.2014.07.014. Epub 2014 Jul 15 Studies using dual-energy X-ray absorptiometry and quantitative computed tomography for longitudinal assessment of changes at the hip have consistently shown increases in areal and volumetric bone … Leer más
THE CONVERGENCE OF FRACTURE REPAIR AND STEM CELLS: INTERPLAY OF GENES, AGING, ENVIRONMENTAL FACTORS AND DISEASE
J Bone Miner Res. 2014 Nov;29(11):2307-22. doi: 10.1002/jbmr.2373. Review studies of bone regeneration in genetically modified mouse models, during aging, following environmental exposure, and in the setting of disease that provide insights regarding the role … Leer más
CONSTITUTIVE EXPRESSION OF GSΑR201C IN MICE PRODUCES A HERITABLE, DIRECT REPLICA OF HUMAN FIBROUS DYSPLASIA BONE PATHOLOGY AND DEMONSTRATES ITS NATURAL HISTORY
J Bone Miner Res. 2014 Nov;29(11):2357-68. doi: 10.1002/jbmr.2267. As in humans, FD lesions in mice developed only in the postnatal life; a defined spatial and temporal pattern characterized the onset and progression of lesions across … Leer más
VEGF RECEPTOR 2 (VEGFR2) ACTIVATION IS ESSENTIAL FOR OSTEOCYTE SURVIVAL INDUCED BY MECHANOTRANSDUCTION.
These in vitro findings point to caveolin-1-dependent VEGFR2 activation as an important mechanism whereby mechanical stimuli promote osteocyte viability
CALCIUM NEPHROLITHIASIS AND BONE DEMINERALIZATION: PATHOPHYSIOLOGY, DIAGNOSIS, AND MEDICAL MANAGEMENT.
Patients with recurrent calcium nephrolithiasis and fasting hypercalciuria have a higher incidence of osteopenia and osteoporosis. They present increased BTMs (mainly resorptive) and up to 30% have hypocitraturia and increased urinary calcium/citrate ratio (>0.25). Medical … Leer más
