In conclusion, our data highlight the potential for novel drug targeting approaches in rare skeletal disorders ranging from severe skeletal fragility to sclerosing bone overgrowth through selective modulation of canonical WNT signaling. These approaches should … Leer más
Calcified Tissue International (2014) 94:4: 423-432 They conclude that Cnr2 deficiency affects expression of a large number of genes in different strains of mice, and that these differences are likely to be responsible in part … Leer más
The results of this nested case–control study in the CPRD indicate no evidence for a higher risk of MI or cardiovascular death associated with the use of strontium ranelate in women treated for osteoporosis compared … Leer más
Osteoporos Int (2014) 25:1225–1235 This is the first network meta-analysis to assess the comparative GI safety of bisphosphonates for primary osteoporosis. Our results identify zoledronic acid as having the highest probability of having the greatest … Leer más
J Bone Miner Res, (2014) 29; 787–795 The findings represent the first demonstration, using a direct in vivo measure of BMS, of compromised bone material properties in patients with T2D. Further, our results confirm previous … Leer más
In conclusion, baseline cardiovascular diseases are common in patients treated with strontium ranelate, with more than half of strontium ranelate users being current users of antiplatelet drugs or having a history of cerebrovascular disease, peripheral … Leer más
Froedtert Healthcare, Patient Care Services, Milwaukee, WI, USA, ryanpa@uwm.edu. Ryan P, Schlidt A, Ryan C Froedtert Healthcare, Patient Care Services, Milwaukee, WI, USA, ryanpa@uwm.edu. Osteoporosis International : a Journal Established as Result of Cooperation Between … Leer más
Vertebral fractures detected “incidentally” by chest radiograph usually do not trigger osteoporosis treatment in older patients. Background Vertebral fractures detected “incidentally” by chest radiograph usually do not trigger osteoporosis treatment in older patients. In a … Leer más
In paired biopsies of osteoporotic women treated with either strontium ranelate or a placebo for 36 months, characteristics of bone apatite crystals were not influenced by the presence of strontium. Summary In paired biopsies of … Leer más
Frederiek van den Bos1,2, Arlene D. Speelman3, Monique Samson1, Marten Munneke4,5, Bastiaan R. Bloem6 and, Harald J. J. Verhaar1 Conclusion: bone loss in PD is multifactorial. It is clinically important because of the concomitant risk … Leer más
