In spite of the fact that this study does not have a large enough sample, our data suggest that HT used in the early years of menopause does not present a long-term protective effect on vertebral … Leer más
The results highlight the PUFA metabolism differences between uninduced and induced MSC to differentiate into adipocytes and osteoblasts, besides the relevant role of the lipoxygenase gene expression in adipogenesis induction. Autor: Casado-Díaz A, Ferreiro-Vera C, Priego-Capote … Leer más
Our results show: (i) retinoic acid affects proliferative and mineralogenic activities in two fish skeletal cell types and (ii) that during phenotype transitions, specific retinoic acid nuclear receptors and bone-related genes are differentially expressed in a … Leer más
The results suggest that deletions in the 6p25.1 locus may predispose to higher risk of fracture in a subset of populations of European origin; larger and geographically restricted studies will be needed to confirm this … Leer más
The results suggest that matrix Gla protein genetic variations could predict a higher risk of bone loss and progression of vascular calcification in men. Two matrix Gla protein (MGP) polymorphisms were associated with progression of … Leer más
The impact on the population of the different recommendations is enormous, varying from 17% to 80% of the population over 50 who would be tested Although in men it seems that a clinical rationale exists … Leer más
Calcif Tissue Int. 2014 Jun;94(6):569-79. doi: 10.1007/s00223-014-9851-x. Epub 2014 Apr 1. The objective of this review is to summarize the recent research on bone cells under microgravity conditions based on advances in the field. Autor: … Leer más
Calcif Tissue Int. 2014 Jun;94(6):597-607. doi: 10.1007/s00223-014-9855-6. Epub 2014 Apr 6. These results provide further evidence that PPI use may increase fracture risk in the elderly and highlight the need for clinicians to periodically reassess … Leer más
Bone 61 (2014) 138–148. This review examines recent developments in the understanding of why the elderly hip becomes fragile. This growing understanding is suggesting novel testable approaches for reducing risk of hip fracture that might translate … Leer más
Mol Endocrinol. 2014 Jul;28(7):1150-65 We conclude that osteocytogenesis is accompanied by changes in gene expression that may be driven by both genetic and epigenetic components. These changes are likely responsible for the osteocyte phenotype and … Leer más
