Role of Periostin in Adhesion and Migration of Bone Remodeling Cells
Role of Periostin in Adhesion and Migration of Bone Remodeling Cells
Clinical effectiveness of orthogeriatric and fracture liaison service models of care for hip fracture patients: population-based longitudinal study
The introduction and/or expansion of orthogeriatric and FLS models of post-hip fracture care has a beneficial effect on subsequent mortality. No evidence for a reduction in second hip fracture rate was found.
Balancing benefits and risks of glucocorticoids in rheumatic diseases and other inflammatory joint disorders: new insights from emerging data
An expert consensus paper from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO). Within a strategy of a disease modifying approach to inflammatory disease, short durations of moderate doses of … Leer más
The COL1A1 SP1 polymorphism is associated with lower bone mineral density in patients treated with valproic acid
In our study, the presence of the ‘s’ allele of the COL1A1 Sp1 polymorphism in individuals with epilepsy was related to lower bone BMD (lumbar and femoral). This relationship seemed to be further apparent in … Leer más
Fracture experience among participants from the FROCAT study: what thresholding is appropriate using the FRAX tool?
Our findings support and validate the use of FRIDEX thresholds of FRAX when discussing the risk of fracture and the initiation of therapy with patients.
Bone-density tests
It’s worth getting a bone-density test if you’re older or have other risk factors for weak bones, because without it the first sign of osteoporosis is usually a broken bone. Autor: © 2011 American Medical … Leer más
Epidemiology of fractures in type 2 diabetes
Bone. 2016 Jan;82:2-8. doi: 10.1016/j.bone.2015.05.032. Epub 2015 May 29. Review. This article is part of a Special Issue entitled “Bone and diabetes” Autor: Schwartz AV
Implications of exercise-induced adipo-myokines in bone metabolism
The beneficial effects of exercise on bone metabolism depends on the intermittent exposure to myokines which, instead, act as inflammatory/pro-resorptive mediators when chronically elevated; on the other hand, the reduction in the circulating levels of … Leer más
Oxidative stress, autophagy, epigenetic changes and regulation by miRNAs as potential therapeutic targets in osteoarthritis
A deeper knowledge of the mechanisms involved in chondrocyte aging could identify potential targets for the treatment of OA, a prevalent and therapeutic-orphan disease.
New PPARγ partial agonist improves obesity-induced metabolic alterations and atherosclerosis in LDLr-/- mice
GQ-177, a new thiazolidinedione, acts as a partial PPARγ agonist that improves obesity-associated insulin resistance and dyslipidemia with atheroprotective effects in LDLr-/- mice.
