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Lithogenic factors in postmenopausal women with osteoporotic fracture.
The aim of this study was to show the presence of phosphorus and calcium metabolism disorders and the presence of urine lithogenic factors in women with osteoporotic fracture without previous urinary lithiasis. A cross-sectional study … Leer más
Generation and characterization of two immortalized human osteoblastic cell lines useful for epigenetic studies.
Different model systems using osteoblastic cell lines have been developed to help understand the process of bone formation. Here, we report the establishment of two human osteoblastic cell lines obtained from primary cultures upon transduction … Leer más
BRCA1 haploinsufficiency cell-autonomously activates RANKL expression and generates denosumab-responsive breast cancer-initiating cells.
Denosumab, a monoclonal antibody to the receptor activator of nuclear factor-κB ligand (RANKL), might be a novel preventative therapy for BRCA1-mutation carriers at high risk of developing breast cancer. They tested the alternative but not … Leer más
The effectiveness of a basic exercise intervention to improve strength and balance in women with osteoporosis.
OBJECTIVE: To determine the effects of a simple exercise program on the balance and strength of postmenopausal women with osteoporosis.CONCLUSION: The present study demonstrates that a physical exercise program based on balance and strength exercises, … Leer más
Paget’s Disease of Bone: Approach to Its Historical Origins.
Paget’s disease of bone is the second most common bone disease after osteoporosis. It is characterized by focal regions of highly exaggerated bone remodeling, with abnormalities in all phases of the remodeling process. This study … Leer más
MicroRNAs in bone diseases.
MicroRNAs are small, noncoding single-stranded RNAs that have emerged as important posttranscriptional regulators of gene expression, with an essential role in vertebrate development and different biological processes. This review highlights the recent advances in the … Leer más
Durability of Response to Zoledronate Treatment and Competing Mortality in Paget’s Disease of Bone
There has been a marked secular trend in recent decades toward patients with Paget’s disease presenting at a greater age and having less extensive skeletal involvement. Over a similar time frame more potent bisphosphonates with … Leer más
