Monthly Archives: diciembre 2016

DOI: 10.5582/irdr.2016.01067 PMCID: PMC5116865 PMID: 27904825 Sclerosing bone dysplasias are a series of clinically and genetically heterogeneous diseases characterized by functional failure of the osteoclasts in  bone resorption, leading to an excessive amount of bone mineral density (BMD) which could have serious clinical consequences. We treated three children affected with seriously high levels of BMD […]

J Bone Miner Metab. 2016 Nov;34(6):655-661.Watch Full Movie Online Streaming Online and Download Metabolic bone disease may appear as a complication of obesity surgery. These data show that the osteoprotegerin and receptor-activator of nuclear factor-κB ligand system is  associated with bone markers and bone mineral density at the lumbar spine after obesity surgery Autor: Balsa […]

Toxicology. 2016 Nov 30. pii: S0300-483X(16)30303-1. doi:10.1016/j.tox.2016.11.017. The aim of the present study is to make a more detailed description of the toxic effects of lead intoxication on bone intrinsic material properties as mineral composition, morphology and microstructural characteristics. Autor: Álvarez-Lloret P, Lee CM, Conti MI, Terrizzi AR, González-López S,Martínez MP.

Prostate. 2016 Nov 3. doi: 10.1002/pros.23270. Prostate cancer frequently expresses an osteomimetic phenotype, but it is unclear how it is regulated and what biological and clinical implications it confers.  MAFF activated osteoblast-like phenotype of prostate cancer cells and altered their responses to osteocyte soluble factors. Autor: González Á, García de Durango C, Alonso V, Bravo […]

Sci Rep. 2016 Nov 2;6:36201. doi: 10.1038/srep36201 This study examines the effects of Wnt/βcatenin signaling in mature osteoclasts by generating mice lacking βcatenin in CathepsinK-expressing cells (Ctnnb1(f/f);CtsKCre mice). Their results indicate that the bone phenotype of Ctnnb1(f/f);CtsKCre animals combines a cell-autonomous effect in the mature osteoclast with indirect effects  due to the additional targeting of […]

Biochem Biophys Res Commun. 2016 Nov 28.Watch Full Movie Online Streaming Online and Download Reactive Oxygen Species (ROS) increase during aging, potentially affecting many tissues including brain, heart, and bone.  ROS alter signaling pathways and constitute potential therapeutic targets to limit oxidative damaging effects in aging-associated diseases.  The role of oxidation on PTHR signaling and […]