Vitamin D3 and calcidiol are not equipotent
Calcidiol is faster and 3-6 times more potent to obtain serum levels of 25(OH)D in the medium to long term.
Antiresorptive treatment, when initiated after a first hip fracture, may not protect of a second contralateral episode in elderly population: A study with 685 patients
There was no significant difference between suffering a second hip fracture and following osteoporosis treatment, using psychotropic drugs or being institutionalised.
AI-related BMD variation in actual practice conditions: a prospective cohort study
Our data confirm a clinically relevant bone loss associated with aromatase inhibitors (AI) therapy amongst non-users of preventative bisphosphonates. We further report on the importance of BMD monitoring as well as calcium and 25(OH)vitD supplementation … Leer más
Bone mineral density decline according to renal tubular dysfunction and phosphaturia in tenofovir-exposed HIV-infected patients
Chronic abnormal phosphaturia explains, at least in part, progressive bone loss during TDF therapy. These data suggest that tubular dysfunction leads to an altered equilibrium between phosphatemia, phosphaturia and bone as mechanism of progressive BMD … Leer más
Effect of osteoporosis medications on fracture healing
Osteoporos Int. 2016 Mar;27(3):861-71. doi: 10.1007/s00198-015-3331-7. Epub 2015 Sep 29 Further clinical studies with these medications are needed to fully understand their effects on fracture healing in order to simultaneously treat fragility fractures and underlying … Leer más
Premios Fundación Lilly de Investigación Biomédica Preclínica y Clínica 2016
La Fundación Lilly, en desarrollo de sus objetivos estatutarios y dentro del programa de Apoyo a la Investigación BIOMÉDICA, convoca los Premios Fundación Lilly de Investigación Biomédica Preclínica y Clínica 2016, para investigadores que hayan … Leer más
The COL1A1 SP1 polymorphism is associated with lower bone mineral density in patients treated with valproic acid
In our study, the presence of the ‘s’ allele of the COL1A1 Sp1 polymorphism in individuals with epilepsy was related to lower bone BMD (lumbar and femoral). This relationship seemed to be further apparent in … Leer más
Global Consensus Recommendations on Prevention and Management of Nutritional Rickets
J Clin Endocrinol Metab. 2016 Feb;101(2):394-415. doi: 10.1210/jc.2015-2175. Epub 2016 Jan 8. Rickets, osteomalacia, and vitamin D and calcium deficiencies are preventable global public health problems in infants, children, and adolescents. Implementation of international rickets … Leer más
Contribution of Lumbar Spine BMD to Fracture Risk in Individuals With T-Score Discordance
J Bone Miner Res. 2016 Feb;31(2):274-80. doi: 10.1002/jbmr.2611. Epub 2015 Sep 3. This study shows the significant contribution of lower LS BMD to fracture risk over and above FN BMD in women. A LS BMD … Leer más
The Microbiome and Musculoskeletal Conditions of Aging: A Review of Evidence for Impact and Potential Therapeutics
J Bone Miner Res. 2016 Feb;31(2):261-9. doi: 10.1002/jbmr.2765. Review. This perspective discusses evidence to date on the role of the microbiome and the highly prevalent age-related disorders of osteoporosis, osteoarthritis, gout, rheumatoid arthritis, sarcopenia, and … Leer más
