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The relative efficacy and harms of balloon kyphoplasty (BK) for treating vertebral compression fractures (VCF) are uncertain. The clinical importance of the greater improvements with BK versus NSM is unclear, may be due to placebo … Leer más

Osteoarthritis (OA) is characterized by degenerative changes in the whole joint leading to physical disability in the elderly population. This condition is associated with altered bone metabolism in subchondral areas suggesting that therapeutic strategies aimed … Leer más

If oversuppression of bone turnover explained the association between bisphosphonate use and atypical subtrochanteric femur fractures (AFF), this could be reversed with anabolic treatment such as teriparatide. They conducted a prospective, open-label study in patients … Leer más

Type 1 and type 2 diabetes are generally accepted to be associated with increased bone fracture risk. However, the pathophysiological mechanisms of diabetic bone disease are poorly understood, and whether the associated increased skeletal fragility … Leer más

A case series of six women with postmenopausal osteoporosis who had received continuous denosumab for 7 years and were then given a single infusion of zoledronate (5 mg) is reported. During denosumab treatment, bone mineral density (BMD) … Leer más

Few studies have investigated the extent to which dietary heavy metals are associated with low bone mineral density. They did not find associations between bone health and the dietary intake of three heavy metals in … Leer más

This narrative review considers the key challenges facing healthcare professionals and policymakers responsible for providing care to populations in relation to bone health. These challenges broadly fall into four distinct themes: (1) case finding and … Leer más

Patients with Down syndrome have a number of risk factors that theoretically could predispose them to osteoporosis. In addition, the bone mass of these people may be affected by their anthropometric and body composition peculiarities. … Leer más

Understanding the molecular events that regulate osteoblast differentiation is essential for the development of effective approaches to bone regeneration. In this study, they analysed the osteoinductive properties of extracellular calcium in bone marrow-derived mesenchymal stem … Leer más