Osteoarthritis (OA) is characterized by degenerative changes in the whole joint leading to physical disability in the elderly population. This condition is associated with altered bone metabolism in subchondral areas suggesting that therapeutic strategies aimed at modifying bone cell metabolism may be of interest. The three PTHrP peptides favored osteoblastic function although the C-terminal domain of PTHrP was more efficient than its N-terminal domain. Our data support an anti-senescence and anti-inflammatory role for the C-terminal moiety of PTHrP with potential applications in chronic inflammatory conditions such as OA.
J Gerontol A Biol Sci Med Sci. 2017 May 1;72(5):624-631. doi:10.1093/gerona/glw100.
Platas J, Guillén MI, Gomar F, Castejón MA, Esbrit P, Alcaraz MJ