CathepsinKCre mediated deletion of βcatenin results in dramatic loss of bone mass by targeting both osteoclasts and osteoblastic cells
Sci Rep. 2016 Nov 2;6:36201. doi: 10.1038/srep36201 This study examines the effects of Wnt/βcatenin signaling in mature osteoclasts by generating mice lacking βcatenin in CathepsinK-expressing cells (Ctnnb1(f/f);CtsKCre mice). Their results indicate that the bone phenotype … Leer más