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CathepsinKCre mediated deletion of βcatenin results in dramatic loss of bone mass by targeting both osteoclasts and osteoblastic cells

Sci Rep. 2016 Nov 2;6:36201. doi: 10.1038/srep36201 This study examines the effects of Wnt/βcatenin signaling in mature osteoclasts by generating mice lacking βcatenin in CathepsinK-expressing cells (Ctnnb1(f/f);CtsKCre mice). Their results indicate that the bone phenotype … Leer más

Parathyroid Hormone Polymorphism RS6254 is Associated with the Development and Severity of Osteoporosis in Asymptomatic but not Normocalcemic Hyperparathyroidism

Horm Metab Res. 2016 Nov 11. Autor: Díaz-Soto G, Romero E, Pérez-Castrillón JL, Jauregui OI, de Luis Román D

Diverging results of areal and volumetric bone mineral density in Down syndrome

Osteoporos Int. 2016 Nov 12. Population with Down syndrome (DS) has lower areal BMD, in association with their smaller skeletal size. However, volumetric BMD and other indices of bone microarchitecture, such as trabecular bone score … Leer más

Oxidation inhibits PTH receptor signaling and trafficking

Biochem Biophys Res Commun. 2016 Nov 28.Watch Full Movie Online Streaming Online and Download Reactive Oxygen Species (ROS) increase during aging, potentially affecting many tissues including brain, heart, and bone. ROS alter signaling pathways and … Leer más

The diabetic paradox: Bone mineral density and fracture in type 2 diabetes

Endocrinol Nutr. 2016 Nov;63(9):495-501. Autor: Botella Martínez S, Varo Cenarruzabeitia N, Escalada San Martin J, Calleja Canelas A.

Biologic therapies and bone loss in rheumatoid arthritis

Osteoporos Int. 2016 Oct 31. [Epub ahead of print] DOI: 10.1007/s00198-016-3769-2 PMID: 27796445 [PubMed – as supplied by publisher] In this review, the authors present the best evidence available regarding bone loss in RA patients. … Leer más

Role and mechanism of action of sclerostin in bone

Bone. 2016 Oct 12. pii: S8756-3282(16)30297-6. doi: 10.1016/j.bone.2016.10.007. [Epub ahead of print] PubMed PMID: 27742498. Autor: Delgado-Calle J, Sato AY, Bellido T.

Parathyroid Hormone Polymorphism RS6254 is Associated with the Development and Severity of Osteoporosis in Asymptomatic but not Normocalcemic Hyperthyroidism

Horm Metab Res. 2016 Oct 18. [Epub ahead of print] PubMed PMID: 27756092. Autor: Díaz-Soto G, Romero E, Pérez-Castrillón JL, Jauregui OI, de Luis Román D.

Osteoporotic Hip Fracture in Spain: A Prospective, 12-Month, Observational Study

Calcif Tissue Int. 2016 Oct 14. [Epub ahead of print] PubMed PMID: 27738719. Autor: Caeiro JR, Bartra A, Mesa-Ramos M, Etxebarría Í, Montejo J, Carpintero P, Sorio F, Gatell S, Farré A, Canals L; PROA … Leer más

In vitro colonization of stratified bioactive scaffolds by pre-osteoblast cells.

Acta Biomater. 2016 Oct 15;44:73-84. doi: 10.1016/j.actbio.2016.08.014. PubMed PMID: 27521495. Autor: Gómez-Cerezo N, Sánchez-Salcedo S, Izquierdo-Barba I, Arcos D, Vallet-Regí M.