Oxidation inhibits PTH receptor signaling and trafficking

Biochem Biophys Res Commun. 2016 Nov 28.Watch Full Movie Online Streaming Online and Download

Reactive Oxygen Species (ROS) increase during aging, potentially affecting many tissues including brain, heart, and bone.  ROS alter signaling pathways and constitute potential therapeutic targets to limit oxidative damaging effects in aging-associated diseases.  The role of oxidation on PTHR signaling and trafficking, and suggest the relevance of ROS as a putative target in diseases associated with oxidative stress such as age-related osteoporosis.

Autor: Ardura JA, Alonso V, Esbrit P, Friedman PA.

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