J Bone Miner Res June; 31(6):1167-1176 . doi: 10.1002/jbmr.2797. Epub 2016 Jan 28. In conclusion, our identification of a novel germline gain-of-function Gα11 mutation, Val340Met, causing ADH2 demonstrates the importance of the Gα11 C-terminal region … Leer más
These results demonstrate the chondroprotective effects of the combination chondroitin sulfate-glucosamine in vivo, in the experimental model of anterior cruciate ligament transection in ovariectomised rats, and suggest that this combination may be useful to control … Leer más
Novel osteoinductive biphasic calcium phosphate particles demonstrate a wide range of significant increases over several key molecules implicated in osteogenesis that may be implicated in their ability to form ectopic bone formation.
One in two real-life users of alendronate exhibited one or more clinical characteristics that would have led to them being excluded from the FIT trial.
Local activation of 1α-hydroxylase in the artery mediates vascular calcification observed in uremia
J Clin Endocrinol Metab. 2016 May;101(5):1945-53. doi: 10.1210/jc.2015-3467. Epub 2016 Jan 18. Preadmission bisphosphonate use was associated with superior survival among critically ill patients. Prospective studies examining the effects of bisphosphonate in critical illness are … Leer más
Osteoporos Int. 2016 May;27(5):1677-82. doi: 10.1007/s00198-016-3553-3. Epub 2016 Mar 1 Patients should be encouraged to continue denosumab therapy long term. If discontinuation does occur, appropriate steps must be taken to prevent the rapid bone loss … Leer más
J Clin Endocrinol Metab. 2016 May;101(5):2226-34. doi: 10.1210/jc.2016-1104. Epub 2016 Mar 23. Previously reported racial differences in DBP concentration are likely from monoclonal assay bias, as there was no racial difference in DBP concentration by … Leer más
This method might be a promising approach for the quantification of cortical bone thickness and density using clinical routine imaging techniques.
J Bone Miner Res. 2016 Apr;31(4):874-81. doi: 10.1002/jbmr.2782. Epub 2016 Jan 24 We demonstrate that impaired sclerostin binding to the mutated LRP4 protein leads to dramatic increase in circulating sclerostin in this patient. With this … Leer más
