Vascular Calcification Induced by Chronic Kidney Disease Is Mediated by an Increase of 1α-Hydroxylase Expression in Vascular Smooth Muscle Cells
Local activation of 1α-hydroxylase in the artery mediates vascular calcification observed in uremia
Chondroprotective effects of the combination chondroitin sulfate-glucosamine in a model of osteoarthritis induced by anterior cruciate ligament transection in ovariectomised rats
These results demonstrate the chondroprotective effects of the combination chondroitin sulfate-glucosamine in vivo, in the experimental model of anterior cruciate ligament transection in ovariectomised rats, and suggest that this combination may be useful to control … Leer más
Preadmission Bisphosphonate and Mortality in Critically Ill Patients
J Clin Endocrinol Metab. 2016 May;101(5):1945-53. doi: 10.1210/jc.2015-3467. Epub 2016 Jan 18. Preadmission bisphosphonate use was associated with superior survival among critically ill patients. Prospective studies examining the effects of bisphosphonate in critical illness are … Leer más
Cancel the denosumab holiday
Osteoporos Int. 2016 May;27(5):1677-82. doi: 10.1007/s00198-016-3553-3. Epub 2016 Mar 1 Patients should be encouraged to continue denosumab therapy long term. If discontinuation does occur, appropriate steps must be taken to prevent the rapid bone loss … Leer más
Free 25-Hydroxyvitamin D: Impact of Vitamin D Binding Protein Assays on Racial-Genotypic Associations
J Clin Endocrinol Metab. 2016 May;101(5):2226-34. doi: 10.1210/jc.2016-1104. Epub 2016 Mar 23. Previously reported racial differences in DBP concentration are likely from monoclonal assay bias, as there was no racial difference in DBP concentration by … Leer más
Technical Note: Cortical thickness and density estimation from clinical CT using a prior thickness-density relationship
This method might be a promising approach for the quantification of cortical bone thickness and density using clinical routine imaging techniques.
The Proteasome Inhibitor Bortezomib Maintains Osteocyte Viability in Multiple Myeloma Patients by Reducing Both Apoptosis and Autophagy: A New Function for Proteasome Inhibitors.
J Bone Miner Res. 2016 Apr;31(4):815-27. doi: 10.1002/jbmr.2741. Epub 2015 Dec 14. Our data identify osteocyte autophagy as a new potential target in MM bone disease and support the use of PIs to maintain osteocyte … Leer más
A Novel Domain-Specific Mutation in a Sclerosteosis Patient Suggests a Role of LRP4 as an Anchor for Sclerostin in Human Bone
J Bone Miner Res. 2016 Apr;31(4):874-81. doi: 10.1002/jbmr.2782. Epub 2016 Jan 24 We demonstrate that impaired sclerostin binding to the mutated LRP4 protein leads to dramatic increase in circulating sclerostin in this patient. With this … Leer más
Differential Effects of Teriparatide and Denosumab on Intact PTH and Bone Formation Indices: AVA Osteoporosis Study
J Clin Endocrinol Metab. 2016 Apr;101(4):1353-63. doi: 10.1210/jc.2015-4181. Epub 2016 Feb 9 We compared effects of teriparatide and denosumab on PTH, bone turnover markers, and bone histomorphometry in osteoporotic postmenopausal women. The findings were inconsistent … Leer más
Effect of Teriparatide on Bone Formation in the Human Femoral Neck
J Clin Endocrinol Metab. 2016 Apr;101(4):1498-505. doi: 10.1210/jc.2015-3698. Epub 2016 Feb 22 TPTD stimulates bone formation rapidly in cancellous and endocortical envelopes of the FN. Our findings provide a mechanistic basis for TPTD-mediated improvement in … Leer más
