Real-Life and RCT Participants: Alendronate Users Versus FITs’ Trial Eligibility Criterion
One in two real-life users of alendronate exhibited one or more clinical characteristics that would have led to them being excluded from the FIT trial.
Vascular Calcification Induced by Chronic Kidney Disease Is Mediated by an Increase of 1α-Hydroxylase Expression in Vascular Smooth Muscle Cells
Local activation of 1α-hydroxylase in the artery mediates vascular calcification observed in uremia
Preadmission Bisphosphonate and Mortality in Critically Ill Patients
J Clin Endocrinol Metab. 2016 May;101(5):1945-53. doi: 10.1210/jc.2015-3467. Epub 2016 Jan 18. Preadmission bisphosphonate use was associated with superior survival among critically ill patients. Prospective studies examining the effects of bisphosphonate in critical illness are … Leer más
Cancel the denosumab holiday
Osteoporos Int. 2016 May;27(5):1677-82. doi: 10.1007/s00198-016-3553-3. Epub 2016 Mar 1 Patients should be encouraged to continue denosumab therapy long term. If discontinuation does occur, appropriate steps must be taken to prevent the rapid bone loss … Leer más
Free 25-Hydroxyvitamin D: Impact of Vitamin D Binding Protein Assays on Racial-Genotypic Associations
J Clin Endocrinol Metab. 2016 May;101(5):2226-34. doi: 10.1210/jc.2016-1104. Epub 2016 Mar 23. Previously reported racial differences in DBP concentration are likely from monoclonal assay bias, as there was no racial difference in DBP concentration by … Leer más
Technical Note: Cortical thickness and density estimation from clinical CT using a prior thickness-density relationship
This method might be a promising approach for the quantification of cortical bone thickness and density using clinical routine imaging techniques.
Effect of Teriparatide on Bone Formation in the Human Femoral Neck
J Clin Endocrinol Metab. 2016 Apr;101(4):1498-505. doi: 10.1210/jc.2015-3698. Epub 2016 Feb 22 TPTD stimulates bone formation rapidly in cancellous and endocortical envelopes of the FN. Our findings provide a mechanistic basis for TPTD-mediated improvement in … Leer más
The National Osteoporosis Foundation’s position statement on peak bone mass development and lifestyle factors: a systematic review and implementation recommendations
Osteoporos Int. 2016 Apr;27(4):1281-386. doi: 10.1007/s00198-015-3440-3. Epub 2016 Feb 8. Erratum in: Osteoporos Int. 2016 Apr;27(4):1387. The best evidence (grade A) is available for positive effects of calcium intake and physical activity, especially during the … Leer más
The National Osteoporosis Foundation’s position statement on peak bone mass development and lifestyle factors: a systematic review and implementation recommendations
Osteoporos Int. 2016 Apr;27(4):1281-386. doi: 10.1007/s00198-015-3440-3. Epub 2016 Feb 8 The best evidence (grade A) is available for positive effects of calcium intake and physical activity, especially during the late childhood and peripubertal years-a critical … Leer más
Osteoporosis in the adult solid organ transplant population: underlying mechanisms and available treatment options
Osteoporos Int. 2016 Apr;27(4):1425-40. doi: 10.1007/s00198-015-3367-8. Epub 2015 Oct 16. Review Supplementation with calcium and vitamin D is often necessary in the SOT population due to a high incidence of vitamin D deficiency. Bisphosphonate therapy … Leer más
