Vascular Calcification Induced by Chronic Kidney Disease Is Mediated by an Increase of 1α-Hydroxylase Expression in Vascular Smooth Muscle Cells
Local activation of 1α-hydroxylase in the artery mediates vascular calcification observed in uremia
Chondroprotective effects of the combination chondroitin sulfate-glucosamine in a model of osteoarthritis induced by anterior cruciate ligament transection in ovariectomised rats
These results demonstrate the chondroprotective effects of the combination chondroitin sulfate-glucosamine in vivo, in the experimental model of anterior cruciate ligament transection in ovariectomised rats, and suggest that this combination may be useful to control … Leer más
Preadmission Bisphosphonate and Mortality in Critically Ill Patients
J Clin Endocrinol Metab. 2016 May;101(5):1945-53. doi: 10.1210/jc.2015-3467. Epub 2016 Jan 18. Preadmission bisphosphonate use was associated with superior survival among critically ill patients. Prospective studies examining the effects of bisphosphonate in critical illness are … Leer más
Cancel the denosumab holiday
Osteoporos Int. 2016 May;27(5):1677-82. doi: 10.1007/s00198-016-3553-3. Epub 2016 Mar 1 Patients should be encouraged to continue denosumab therapy long term. If discontinuation does occur, appropriate steps must be taken to prevent the rapid bone loss … Leer más
Free 25-Hydroxyvitamin D: Impact of Vitamin D Binding Protein Assays on Racial-Genotypic Associations
J Clin Endocrinol Metab. 2016 May;101(5):2226-34. doi: 10.1210/jc.2016-1104. Epub 2016 Mar 23. Previously reported racial differences in DBP concentration are likely from monoclonal assay bias, as there was no racial difference in DBP concentration by … Leer más
Technical Note: Cortical thickness and density estimation from clinical CT using a prior thickness-density relationship
This method might be a promising approach for the quantification of cortical bone thickness and density using clinical routine imaging techniques.
Osteoporosis in the adult solid organ transplant population: underlying mechanisms and available treatment options
Osteoporos Int. 2016 Apr;27(4):1425-40. doi: 10.1007/s00198-015-3367-8. Epub 2015 Oct 16. Review Supplementation with calcium and vitamin D is often necessary in the SOT population due to a high incidence of vitamin D deficiency. Bisphosphonate therapy … Leer más
Differential Effects of Teriparatide and Denosumab on Intact PTH and Bone Formation Indices: AVA Osteoporosis Study
J Clin Endocrinol Metab. 2016 Apr;101(4):1353-63. doi: 10.1210/jc.2015-4181. Epub 2016 Feb 9. We compared effects of teriparatide and denosumab on PTH, bone turnover markers, and bone histomorphometry in osteoporotic postmenopausal women. The findings were inconsistent … Leer más
Sodium Intake and Osteoporosis. Findings From the Women’s Health Initiative
J Clin Endocrinol Metab. 2016 Apr;101(4):1414-21. doi: 10.1210/jc.2015-4017. Epub 2016 Feb 10. In this large, prospective, observational cohort study of postmenopausal women in the WHI, Cox proportional hazard regression models showed that sodium intake at … Leer más
Evaluation of efficacy and safety of conjugated estrogens/bazedoxifene in a Latin American population
Conjugated estrogens/bazedoxifene improved vasomotor symptoms, genitourinary syndrome of menopause, and BMD in Latin American women, with efficacy/safety similar to the global population.
