Osteoporosis in the adult solid organ transplant population: underlying mechanisms and available treatment options

Osteoporos Int. 2016 Apr;27(4):1425-40. doi: 10.1007/s00198-015-3367-8. Epub 2015 Oct 16. Review

Supplementation with calcium and vitamin D is often necessary in the SOT population due to a high incidence of vitamin D deficiency. Bisphosphonate therapy is most commonly used for prevention and treatment of osteoporosis, but therapy can be limited by renal dysfunction which is common in transplant recipients. Alternative agents such as teriparatide and calcitonin have not been shown to provide a significant impact on the rate of fractures in this population. Additionally, denosumab may be a promising treatment option due to its novel mechanism of action, and is currently being studied in renal transplant patients. Timely initiation of supplementation and treatment, and minimizing glucocorticoid exposure prior to and after transplantation will aid in the prevention and proper management of osteoporosis in these patients.

Autor: Early C, Stuckey L, Tischer S.
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