Vitamin D3 and calcidiol are not equipotent
Calcidiol is faster and 3-6 times more potent to obtain serum levels of 25(OH)D in the medium to long term.
Differential Effects of Teriparatide and Zoledronic Acid on Bone Mineralization Density Distribution at 6 and 24 Months in the SHOTZ Study
J Bone Miner Res. 2016; 31(8):1527-35. doi: 10.1002/jbmr.2825. Epub 2016 Mar 30. TPTD stimulated new bone formation, producing a mineralized bone matrix that remained relatively heterogeneous with a stable mean mineral content. ZOL slowed bone … Leer más
Mortality After Atypical Femoral Fractures: A Cohort Study
J Bone Miner R 2016 Mar;31(3):491-7. doi: 10.1002/jbmr.2767. Epub 2016 Jan 8 We conclude that in contrast to ordinary subtrochanteric and femoral shaft fractures, atypical femoral fractures are not associated with excess mortalityes. Autor: Kharazmi … Leer más
Dietary Patterns and Fractures in Postmenopausal Women: Results From the Women’s Health Initiative
JAMA Intern Med. 2016 Mar 28. doi: 10.1001/jamainternmed.2016.0482. [Epub ahead of print] Higher adherence to a Mediterranean diet is associated with a lower risk for hip fractures. These results support that a healthy dietary pattern … Leer más
MicroRNA variants as genetic determinants of bone mass
Bone. 2016 Mar;84:57-68. doi: 10.1016/j.bone.2015.12.016. Epub 2015 Dec 23. Review. Given the polygenic nature of skeletal diseases like osteoporosis and osteoarthritis, validating the function of additional miRNA-associated SNPs has the potential to enhance our understanding … Leer más
Osteocyte-directed bone demineralization along canaliculi
Bone. 2016 Mar;84:279-88. doi: 10.1016/j.bone.2015.12.006. Epub 2015 Dec 17 These data suggest demineralization can occur from within bone through the canalicular system, and that peri-canalicular demineralization occurs not uniformly but directed by individual osteocytes. Blockade … Leer más
Bisphosphonate drug holidays: we reap what we sow
Osteoporos Int. 2016 Mar;27(3):849-52. doi: 10.1007/s00198-015-3453-y. Epub 2015 Dec 14. No abstract available. Clinicians need to rethink the assumption that a patient who has taken an oral bisphosphonate for 5 years or an intravenous therapy … Leer más
Effect of osteoporosis medications on fracture healing
Osteoporos Int. 2016 Mar;27(3):861-71. doi: 10.1007/s00198-015-3331-7. Epub 2015 Sep 29 Further clinical studies with these medications are needed to fully understand their effects on fracture healing in order to simultaneously treat fragility fractures and underlying … Leer más
Bone mineral density decline according to renal tubular dysfunction and phosphaturia in tenofovir-exposed HIV-infected patients
Chronic abnormal phosphaturia explains, at least in part, progressive bone loss during TDF therapy. These data suggest that tubular dysfunction leads to an altered equilibrium between phosphatemia, phosphaturia and bone as mechanism of progressive BMD … Leer más
AI-related BMD variation in actual practice conditions: a prospective cohort study
Our data confirm a clinically relevant bone loss associated with aromatase inhibitors (AI) therapy amongst non-users of preventative bisphosphonates. We further report on the importance of BMD monitoring as well as calcium and 25(OH)vitD supplementation … Leer más
