Comparison of two different strategies of treatment with zoledronate in HIV-infected patients with low bone mineral density: single dose versus two doses in 2 years
The benefits for BMD of a single dose of zoledronate in 2 years may be comparable to those obtained with two doses of the drug after 96 weeks, although this study is insufficiently powered to … Leer más
Use of proton pump inhibitors is associated with fractures in young adults: a population-based study
Osteoporos Int 19 may 2015 on line. DOI 10.1007/s00198-015-3168-0 PPI use was associated with fracture in young adults, but overall evidence did not support a PPI-fracture relationship in children. Young adults who use PPIs should … Leer más
Improvement of mineral and bone metabolism markers is associated with better survival in haemodialysis patients: the COSMOS study
COSMOS provides evidence of the association of serum phosphorus, calcium and PTH and mortality, and suggests survival benefits of controlling chronic kidney disease-mineral and bone disorder biochemical parameters in CKD5D patients.
Bone strength and muscle properties in postmenopausal women with and without a recent distal radius fracture
Osteoporos Int 19 May online 2015. DOI 10.1007/s00198-015-3160-8 Postmenopausal women aged 50 years and older with a recent DRF had lower bone and muscle strength in both the upper and lower extremities com- pared to … Leer más
DLK1 regulates whole body glucose metabolism: A negative feedback regulation of the osteocalcin-insulin loop
Our data suggest that Glu-OCN-controlled production of Delta like-1 (DLK1) by pancreatic β cells acts as a negative feedback mechanism to counteract the stimulatory effects of insulin on osteoblast production of Glu-OCN, a potential mechanism … Leer más
Co-administration of Antiresorptive and Anabolic Agents: A Missed Opportunity
J Bone Miner Res. 2015 May;30(5):753-64. doi: 10.1002/jbmr.2496. Combined therapy remains a potentially valuable approach to therapy. Because studies of antifracture efficacy comparing combined with single therapy are unlikely to be performed in humans, efforts … Leer más
Establishing Biomechanical Mechanisms in Mouse Models: Practical Guidelines for Systematically Evaluating Phenotypic Changes in the Diaphyses of Long Bones
Journal of Bone and Mineral Research 2015; Volume 30, Issue 6, pages 951–966 The goal of this review is to clarify the biomechanical mechanisms and to make recommendations for systematically evaluating phenotypic changes in mouse … Leer más
Hyponatremia and Fractures: Findings From the MrOS Study
Journal of Bone and Mineral Research 2015; Volume 30, Issue 6, pages 970–975 The data show that hyponatremia is associated with up to a doubling in the risk of hip and morphometric spine fractures, independent … Leer más
Inappropriate prescribing to the oldest old patients admitted to hospital: prevalence, most frequently used medicines, and associated factors
Prescribed medicines and potentially inappropriate medicines (PIM) and potentially prescribing omissions (PPO) prevalence were high among patients 85 years and over. Benzodiazepine use in those who are prone to falls and omission of calcium and … Leer más
