Osteosarcopenic obesity and fall prevention strategies.
A therapeutic approach to osteosarcopenic obesity aimed at the prevention of falls must include several factors, and act on those risk elements which can be effectively modified.
p38α function in osteoblasts influences adipose tissue homeostasis.
Altogether, these results further suggest that, in addition to osteocalcin, other bone-derived signals affect white adipose tissue and energy expenditure contributing to the regulation of energy metabolism.
Socio-economic status and its association with the risk of developing hip fractures: a region-wide ecological study.
Wealthiest areas have an almost 30% increased risk of hip fracture compared to the most deprived. Differences in age-sex composition and a higher prevalence of obesity in deprived areas could explain this higher risk.
DIAGNOSIS AND MANAGEMENT OF OSTEONECROSIS OF THE JAW: A SYSTEMATIC REVIEW AND INTERNATIONAL CONSENSUS
J Bone Miner Res. 2015 Jan;30(1):3-23. doi: 10.1002/jbmr.2405. Prevention strategies for ONJ include elimination or stabilization of oral disease prior to initiation of antiresorptive agents, as well as maintenance of good oral hygiene. In those … Leer más
GREMLIN 1 IDENTIFIES A SKELETAL STEM CELL WITH BONE, CARTILAGE, AND RETICULAR STROMAL POTENTIAL
Cell. 2015 Jan 15;160(1-2):269-84. doi: 10.1016/j.cell.2014.11.042. Grem1 expression identifies distinct connective tissue stem cells in both the bone (OCR stem cells) and the intestine (iRSCs). Autor: Worthley DL, Churchill M, Compton JT, Tailor Y, Rao … Leer más
Comparative Effects of Teriparatide, Denosumab, and Combination Therapy on Peripheral Compartmental Bone Density, Microarchitecture, and Estimated Strength: the DATA-HRpQCT Study
J Bone Miner Res. 2015 Jan;30(1):39-45. doi: 10.1002/jbmr.2315. Together, these findings suggest that the use of denosumab and teriparatide in combination improves HR-pQCT measures of bone quality more than either drug alone and may be … Leer más
REFERENCE INTERVALS FOR BONE TURNOVER MARKERS AND THEIR ASSOCIATION WITH INCIDENT HIP FRACTURES IN OLDER MEN: THE HEALTH IN MEN STUDY
J Clin Endocrinol Metab. 2015 Jan;100(1):90-9. doi: 10.1210/jc.2014-2646. Reference intervals for BTMs in older men have been defined. tOC may be more informative for hip fracture risk in older men than CTX-I and PINP. Further … Leer más
STEM CELLS AND BONE: A HISTORICAL PERSPECTIVE
Bone. 2015 Jan;70C:2-9. doi: 10.1016/j.bone.2014.08.011. Current interest in stem cells in bone as in other fields is intertwined with that shift. New opportunities and also new challenges arise. This article is part of a Special … Leer más
The effects of calcium supplementation on verified coronary heart disease hospitalization and death in postmenopausal women: a collaborative meta-analysis of randomized controlled trials
J Bone Miner Res. 2015 Jan;30(1):165-75. doi: 10.1002/jbmr.2311. In conclusion, current evidence does not support the hypothesis that calcium supplementation with or without vitamin D increases coronary heart disease or all-cause mortality risk in elderly … Leer más
OSTEOCYTES MEDIATE THE ANABOLIC ACTIONS OF CANONICAL Wnt/β-catenin SIGNALING IN BONE
Proc Natl Acad Sci U S A. 2015 Jan 20. pii: 201409857. Thus, activation of osteocytic β-catenin signaling increases both osteoclasts and osteoblasts, leading to bone gain, and is sufficient to activate the Notch pathway. … Leer más
