J Bone Miner Res. 2014 Nov;29(11):2357-68. doi: 10.1002/jbmr.2267. As in humans, FD lesions in mice developed only in the postnatal life; a defined spatial and temporal pattern characterized the onset and progression of lesions across … Leer más
Endogenous estrogens partially reduce atherogenic burden in female apolipoprotein E-deficient mice. Ovariectomy increases bone resorption, but not under exacerbated proatherogenic conditions induced by high-fat diet. The absence of apolipoprotein E might have an influence on … Leer más
Osteoporosis and fragility fracture have been diagnosed, although rarely. The condition, however, is transitory because there is no long-term data supporting the deleterious effect of pregnancy on bone mass or fracture risk. Prevention is limited … Leer más
These in vitro findings point to caveolin-1-dependent VEGFR2 activation as an important mechanism whereby mechanical stimuli promote osteocyte viability
Patients with recurrent calcium nephrolithiasis and fasting hypercalciuria have a higher incidence of osteopenia and osteoporosis. They present increased BTMs (mainly resorptive) and up to 30% have hypocitraturia and increased urinary calcium/citrate ratio (>0.25). Medical … Leer más
The European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) recommends optimal dietary protein intake of 1.0-1.2g/kgbodyweight/d with at least 20-25g of high-quality protein at each main meal, with adequate vitamin D … Leer más
We have demonstrated in vivo a key role of nuclear factor erythroid derived 2-related factor-2 (Nrf2) in the maintenance of bone microarchitecture.
Bone turnover markers, BMD and bone microstructural changes in osteoporosis are opposite to those of OA. These findings justify a less resistant bone with higher risk of fragility fractures in OP patients. These histomorphometric and … Leer más
Switching from tenofovir to abacavir led to a slight improvement in femoral BMD although no differences were detected between groups. Larger studies are necessary before firm recommendations can be made on the discontinuation of tenofovir … Leer más
Although scarce data are available, interesting opportunities are open for a better understanding of the pharmacogenetics of osteoporosis and osteoporotic fractures. They include the reanalysis of data already available from epidemiological studies and clinical trials, … Leer más
