A New Role For 5-methoxytryptophol On Bone Cells Function In Vitro.
In conclusion, the present study demonstrates a new role of 5-methoxytryptophol inhibiting osteoclastogenesis and promoting osteoblast differentiation.
Relationship of Dickkopf1 (DKK1) with Cardiovascular Disease and Bone Metabolism in Caucasian Type 2 Diabetes Mellitus.
In summary, circulating DKK1 levels are higher in Type 2 Diabetes Mellitus with Cardiovascular Disease and are associated with an abnormal carotid intima media thickness in this cross-sectional study. DKK1 may be involved in vascular … Leer más
Gaucher disease and bone manifestations
Calcif Tissue Int. 2014 Dec;95(6):477-94. doi: 10.1007/s00223-014-9923-y We have conducted a systematic review of all the various aspects of Gaucher disease, focusing on different skeletal manifestations, pathophysiology of bone alterations, clinical symptoms, and current diagnostic … Leer más
CONSTITUTIVE EXPRESSION OF GSΑR201C IN MICE PRODUCES A HERITABLE, DIRECT REPLICA OF HUMAN FIBROUS DYSPLASIA BONE PATHOLOGY AND DEMONSTRATES ITS NATURAL HISTORY
J Bone Miner Res. 2014 Nov;29(11):2357-68. doi: 10.1002/jbmr.2267. As in humans, FD lesions in mice developed only in the postnatal life; a defined spatial and temporal pattern characterized the onset and progression of lesions across … Leer más
Literature review: The effects of teriparatide therapy at the hip in patients with osteoporosis
Bone 67; 246–256. doi: 10.1016/j.bone.2014.07.014. Epub 2014 Jul 15 Studies using dual-energy X-ray absorptiometry and quantitative computed tomography for longitudinal assessment of changes at the hip have consistently shown increases in areal and volumetric bone … Leer más
THE CONVERGENCE OF FRACTURE REPAIR AND STEM CELLS: INTERPLAY OF GENES, AGING, ENVIRONMENTAL FACTORS AND DISEASE
J Bone Miner Res. 2014 Nov;29(11):2307-22. doi: 10.1002/jbmr.2373. Review studies of bone regeneration in genetically modified mouse models, during aging, following environmental exposure, and in the setting of disease that provide insights regarding the role … Leer más
IMPACT OF ESTROGENS ON ATHEROSCLEROSIS AND BONE IN THE APOLIPOPROTEIN E-DEFICIENT MOUSE MODEL.
Endogenous estrogens partially reduce atherogenic burden in female apolipoprotein E-deficient mice. Ovariectomy increases bone resorption, but not under exacerbated proatherogenic conditions induced by high-fat diet. The absence of apolipoprotein E might have an influence on … Leer más
ENDOCRINOLOGY IN PREGNANCY: BONE METABOLIC CHANGES DURING PREGNANCY: A PERIOD OF VULNERABILITY TO OSTEOPOROSIS AND FRACTURE.
Osteoporosis and fragility fracture have been diagnosed, although rarely. The condition, however, is transitory because there is no long-term data supporting the deleterious effect of pregnancy on bone mass or fracture risk. Prevention is limited … Leer más
VEGF RECEPTOR 2 (VEGFR2) ACTIVATION IS ESSENTIAL FOR OSTEOCYTE SURVIVAL INDUCED BY MECHANOTRANSDUCTION.
These in vitro findings point to caveolin-1-dependent VEGFR2 activation as an important mechanism whereby mechanical stimuli promote osteocyte viability
CALCIUM NEPHROLITHIASIS AND BONE DEMINERALIZATION: PATHOPHYSIOLOGY, DIAGNOSIS, AND MEDICAL MANAGEMENT.
Patients with recurrent calcium nephrolithiasis and fasting hypercalciuria have a higher incidence of osteopenia and osteoporosis. They present increased BTMs (mainly resorptive) and up to 30% have hypocitraturia and increased urinary calcium/citrate ratio (>0.25). Medical … Leer más
