In our study, the presence of the ‘s’ allele of the COL1A1 Sp1 polymorphism in individuals with epilepsy was related to lower bone BMD (lumbar and femoral). This relationship seemed to be further apparent in … Leer más
Our findings support and validate the use of FRIDEX thresholds of FRAX when discussing the risk of fracture and the initiation of therapy with patients.
It’s worth getting a bone-density test if you’re older or have other risk factors for weak bones, because without it the first sign of osteoporosis is usually a broken bone. Autor: © 2011 American Medical … Leer más
Osteoporos Int. 2016 Jan;27(1):161-70. doi: 10.1007/s00198-015-3226-7. Epub 2015 Jul 16. Myostatin deficiency partially improved the reduced femoral bone biomechanical strength of adult +/oim mice by increasing muscle mass with concomitant improvements in bone microarchitecture and … Leer más
J Bone Miner Res. 2016 Jan;31(1):16-35. doi: 10.1002/jbmr.2708. Review. Hence, the Task Force suggests that after 5 years of oral BP or 3 years of intravenous BP, reassessment of risk should be considered. In women … Leer más
J Bone Miner Res. 2016 Jan;31(1):208-14. doi: 10.1002/jbmr.2594. Epub 2015 Aug 4. These data indicate that muscle weakness is an independent determinant of fracture risk in men, but not in women. This sex difference suggests … Leer más
Bone. 2016 Jan;82:2-8. doi: 10.1016/j.bone.2015.05.032. Epub 2015 May 29. Review. This article is part of a Special Issue entitled “Bone and diabetes” Autor: Schwartz AV
The beneficial effects of exercise on bone metabolism depends on the intermittent exposure to myokines which, instead, act as inflammatory/pro-resorptive mediators when chronically elevated; on the other hand, the reduction in the circulating levels of … Leer más
A deeper knowledge of the mechanisms involved in chondrocyte aging could identify potential targets for the treatment of OA, a prevalent and therapeutic-orphan disease.
GQ-177, a new thiazolidinedione, acts as a partial PPARγ agonist that improves obesity-associated insulin resistance and dyslipidemia with atheroprotective effects in LDLr-/- mice.
